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NCT06668064Active, not recruitingPhase 3

A 2-year Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD) (LUGANO) Primary Efficacy Will be Determined at Week 56

A 2-year Phase 3, Multicenter, Prospective, Randomized, Double-Masked, Parallel-Group Study of EYP-1901, a Tyrosine Kinase Inhibitor (TKI), Compared to Aflibercept in Subjects With Wet AMD

Source: ClinicalTrials.gov · Last updated 3 Sept 2026

Brief summary (registry, in English)

This is a phase 3 randomized, double -masked study comparing the efficacy of EYP-1901 against Aflibercept.

Status (registry)
Active, not recruiting
Phase (registry)
Phase 3
Study type
Interventional
Enrollment
400 (estimated)
First submitted
30 Oct 2024
Start date
22 Oct 2024
Primary completion date
13 Jul 2026
Lead sponsor
EyePoint Pharmaceuticals, Inc.
NCT number
NCT06668064

What you commit to

  • Study type: Interventional · Phase 3
  • Planned participants: 400
  • From 22 Oct 2024 to the primary completion date, 13 Jul 2026
  • 76 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other

  • Subfoveal fibrosis, atrophy, or scarring in the center subfield.
  • BCVA using ETDRS charts \<20 letters (20/400 Snellen equivalent) in the fellow eye.

Who the study is looking for

  • Previously treated or treatment naïve patients with a documented diagnosis of wAMD in the study eye, with onset of disease that began at any time prior to the Screening Visit.
  • Best Corrected Visual Acuity (BCVA) by Early Treatment Diabetic Retinopathy Study (ETDRS) letter score between 78 to 35 letters (approximately 20/32 to 20/200 Snellen equivalent) in the study eye at the Screening Visit and on Baseline (Day 1).
  • For previously-treated subjects, must have been treated with at least 2 anti-VEGF IVT injections (i.e., aflibercept 2 mg, aflibercept 8 mg, bevacizumab, ranibizumab, or faricimab) in the previous 6 months for wAMD per standard of care in the study eye prior to the Screening Visit.

Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (76)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Retina Research Institute of Texas Integrated Clinical Research
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AbileneUnited StatesUnknown status
Retina Consultants of Hawaii
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‘AieaUnited StatesUnknown status
Vision Research Center at Eye Associates of New Mexico
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AlbuquerqueUnited StatesUnknown status
Western Carolina Retinal Associates, PA
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AshevilleUnited StatesUnknown status
California Retina Consultants
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BakersfieldUnited StatesUnknown status
The Retina Care Center
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BaltimoreUnited StatesUnknown status
Retina Consultants of Texas (Retina Consultants of Houston) - Woodlands
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BellaireUnited StatesUnknown status
Retina and Vitreous of Texas
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BellaireUnited StatesUnknown status
Retina-Vitreous Associates Medical Group
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Beverly HillsUnited StatesUnknown status
Ophthalmic Consultants of Boston OCB - Boston
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BostonUnited StatesUnknown status
Midwest Eye Institute
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CarmelUnited StatesUnknown status
Retina Consultants
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CharlestonUnited StatesUnknown status
Retina Groups of Washington
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Chevy ChaseUnited StatesUnknown status
Texas Retina Associates
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DallasUnited StatesUnknown status
Connecticut Eye Consultants, P.C.
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DanburyUnited StatesUnknown status
Advanced Research LLC
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Deerfield BeachUnited StatesUnknown status
RSC Research, PLLC
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DenverUnited StatesUnknown status
Retina Associates
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ElmhurstUnited StatesUnknown status
Erie Retina Research
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ErieUnited StatesUnknown status
Verum Research, LLC
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EugeneUnited StatesUnknown status
The Retina Group of Washington
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FairfaxUnited StatesUnknown status
Palmetto Retina Center
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FlorenceUnited StatesUnknown status
Eye Center of Northern Colorado, PC
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Fort CollinsUnited StatesUnknown status
Charles Retina Institute
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GermantownUnited StatesUnknown status
Macula and Retina Institute
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GlendaleUnited StatesUnknown status
Retina Associates of Michigan
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Grand BlancUnited StatesUnknown status
Foundation for Vision Research
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Grand RapidsUnited StatesUnknown status
Retina Consultants of Carolina, P.A.
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GreenvilleUnited StatesUnknown status
SightSera Clinical Research LLC
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GreenwichUnited StatesUnknown status
Cumberland Valley Retina Consultants
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HagerstownUnited StatesUnknown status
Eye Care Specialists - Kingston Location
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KingstonUnited StatesUnknown status
Florida Retina Consultants
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LakelandUnited StatesUnknown status
University Retina and Macula Associates
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LemontUnited StatesUnknown status
Retina Associates LLC
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LenexaUnited StatesUnknown status
Retina Vitreous Surgeons of CNY, PC
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LiverpoolUnited StatesUnknown status
Advanced Vision Institute
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LongmontUnited StatesUnknown status
Piedmont Eye Center
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LynchburgUnited StatesUnknown status
University of Wisconsin School of Medicine and Public Health (UWSMPH)
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MadisonUnited StatesUnknown status
Gerogia Retina
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MariettaUnited StatesUnknown status
Florida Retina Institute
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OrlandoUnited StatesUnknown status
Retina Specialty Institute
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PensacolaUnited StatesUnknown status
Retinal Research Institute, LLC
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PhoenixUnited StatesUnknown status
Eye Associates of Pinellas
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Pinellas ParkUnited StatesUnknown status
Texas Retina Associates
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PlanoUnited StatesUnknown status
Maine Eye Center
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PortlandUnited StatesUnknown status
Retina Consultants San Diego
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PowayUnited StatesUnknown status
Retina Consultants of Southern California
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RedlandsUnited StatesUnknown status
Sierra Eye Associates
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RenoUnited StatesUnknown status
Retina Associates of Western NY, PC
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RochesterUnited StatesUnknown status
Retinal Consultants Medical Group
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SacramentoUnited StatesUnknown status
Retina Associates of Utah
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Salt Lake CityUnited StatesUnknown status
San Antonio Eye Center
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San AntonioUnited StatesUnknown status
Retinal Consultants of Texas
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San AntonioUnited StatesUnknown status
Retina Consultants PLLC
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SlingerlandsUnited StatesUnknown status
Deep Blue Retina Clinical Research PLLC
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SouthavenUnited StatesUnknown status
MedEye Associates
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South MiamiUnited StatesUnknown status
Retina Partners of Northwest Arkansas
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SpringdaleUnited StatesUnknown status
New England Retina Consultants
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SpringfieldUnited StatesUnknown status
The Retina Institute
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St LouisUnited StatesUnknown status
Retina Specialists of Tampa
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TampaUnited StatesUnknown status
Retina Vitreous Associates of Florida
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TampaUnited StatesUnknown status
NJ Retina
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TeaneckUnited StatesUnknown status
Retina Consultants of Texas
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The WoodlandsUnited StatesUnknown status
NJ Retina
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Toms RiverUnited StatesUnknown status
Retina Specialists
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TowsonUnited StatesUnknown status
Tulsa Retina Consultant
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TulsaUnited StatesUnknown status
Tyler Retina Consultants
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TylerUnited StatesUnknown status
Bay Area Retina Associates
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Walnut CreekUnited StatesUnknown status
Retina Group of New England, PC
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WaterfordUnited StatesUnknown status
Salt Lake Retina
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West JordanUnited StatesUnknown status
American Institute of Research
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WhittierUnited StatesUnknown status
Strategic Clinical Research Group, LLC
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Willow ParkUnited StatesUnknown status
Cape Fear Retinal Associates, PC
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WilmingtonUnited StatesUnknown status
Retina Associates, P.C.
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WinchesterUnited StatesUnknown status
Piedmont Retina Specialists, P.A. - Winston-Salem Office
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Winston-SalemUnited StatesUnknown status
Center for Retina & Macular Disease
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Winter HavenUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.