NCT06668064Active, not recruitingPhase 3
A 2-year Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD) (LUGANO) Primary Efficacy Will be Determined at Week 56
A 2-year Phase 3, Multicenter, Prospective, Randomized, Double-Masked, Parallel-Group Study of EYP-1901, a Tyrosine Kinase Inhibitor (TKI), Compared to Aflibercept in Subjects With Wet AMD
Source: ClinicalTrials.gov · Last updated 3 Sept 2026
Brief summary (registry, in English)
This is a phase 3 randomized, double -masked study comparing the efficacy of EYP-1901 against Aflibercept.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 400 (estimated)
- First submitted
- 30 Oct 2024
- Start date
- 22 Oct 2024
- Primary completion date
- 13 Jul 2026
- Lead sponsor
- EyePoint Pharmaceuticals, Inc.
- Diseases
- Macular degeneration
- NCT number
- NCT06668064
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 400
- From 22 Oct 2024 to the primary completion date, 13 Jul 2026
- 76 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Subfoveal fibrosis, atrophy, or scarring in the center subfield.
- BCVA using ETDRS charts \<20 letters (20/400 Snellen equivalent) in the fellow eye.
Who the study is looking for
- Previously treated or treatment naïve patients with a documented diagnosis of wAMD in the study eye, with onset of disease that began at any time prior to the Screening Visit.
- Best Corrected Visual Acuity (BCVA) by Early Treatment Diabetic Retinopathy Study (ETDRS) letter score between 78 to 35 letters (approximately 20/32 to 20/200 Snellen equivalent) in the study eye at the Screening Visit and on Baseline (Day 1).
- For previously-treated subjects, must have been treated with at least 2 anti-VEGF IVT injections (i.e., aflibercept 2 mg, aflibercept 8 mg, bevacizumab, ranibizumab, or faricimab) in the previous 6 months for wAMD per standard of care in the study eye prior to the Screening Visit.
Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers
Sites (76)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Retina Research Institute of Texas Integrated Clinical Research Coordinator of this site? Confirm its status | Abilene | United States | Unknown status |
| Retina Consultants of Hawaii Coordinator of this site? Confirm its status | ‘Aiea | United States | Unknown status |
| Vision Research Center at Eye Associates of New Mexico Coordinator of this site? Confirm its status | Albuquerque | United States | Unknown status |
| Western Carolina Retinal Associates, PA Coordinator of this site? Confirm its status | Asheville | United States | Unknown status |
| California Retina Consultants Coordinator of this site? Confirm its status | Bakersfield | United States | Unknown status |
| The Retina Care Center Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| Retina Consultants of Texas (Retina Consultants of Houston) - Woodlands Coordinator of this site? Confirm its status | Bellaire | United States | Unknown status |
| Retina and Vitreous of Texas Coordinator of this site? Confirm its status | Bellaire | United States | Unknown status |
| Retina-Vitreous Associates Medical Group Coordinator of this site? Confirm its status | Beverly Hills | United States | Unknown status |
| Ophthalmic Consultants of Boston OCB - Boston Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Midwest Eye Institute Coordinator of this site? Confirm its status | Carmel | United States | Unknown status |
| Retina Consultants Coordinator of this site? Confirm its status | Charleston | United States | Unknown status |
| Retina Groups of Washington Coordinator of this site? Confirm its status | Chevy Chase | United States | Unknown status |
| Texas Retina Associates Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Connecticut Eye Consultants, P.C. Coordinator of this site? Confirm its status | Danbury | United States | Unknown status |
| Advanced Research LLC Coordinator of this site? Confirm its status | Deerfield Beach | United States | Unknown status |
| RSC Research, PLLC Coordinator of this site? Confirm its status | Denver | United States | Unknown status |
| Retina Associates Coordinator of this site? Confirm its status | Elmhurst | United States | Unknown status |
| Erie Retina Research Coordinator of this site? Confirm its status | Erie | United States | Unknown status |
| Verum Research, LLC Coordinator of this site? Confirm its status | Eugene | United States | Unknown status |
| The Retina Group of Washington Coordinator of this site? Confirm its status | Fairfax | United States | Unknown status |
| Palmetto Retina Center Coordinator of this site? Confirm its status | Florence | United States | Unknown status |
| Eye Center of Northern Colorado, PC Coordinator of this site? Confirm its status | Fort Collins | United States | Unknown status |
| Charles Retina Institute Coordinator of this site? Confirm its status | Germantown | United States | Unknown status |
| Macula and Retina Institute Coordinator of this site? Confirm its status | Glendale | United States | Unknown status |
| Retina Associates of Michigan Coordinator of this site? Confirm its status | Grand Blanc | United States | Unknown status |
| Foundation for Vision Research Coordinator of this site? Confirm its status | Grand Rapids | United States | Unknown status |
| Retina Consultants of Carolina, P.A. Coordinator of this site? Confirm its status | Greenville | United States | Unknown status |
| SightSera Clinical Research LLC Coordinator of this site? Confirm its status | Greenwich | United States | Unknown status |
| Cumberland Valley Retina Consultants Coordinator of this site? Confirm its status | Hagerstown | United States | Unknown status |
| Eye Care Specialists - Kingston Location Coordinator of this site? Confirm its status | Kingston | United States | Unknown status |
| Florida Retina Consultants Coordinator of this site? Confirm its status | Lakeland | United States | Unknown status |
| University Retina and Macula Associates Coordinator of this site? Confirm its status | Lemont | United States | Unknown status |
| Retina Associates LLC Coordinator of this site? Confirm its status | Lenexa | United States | Unknown status |
| Retina Vitreous Surgeons of CNY, PC Coordinator of this site? Confirm its status | Liverpool | United States | Unknown status |
| Advanced Vision Institute Coordinator of this site? Confirm its status | Longmont | United States | Unknown status |
| Piedmont Eye Center Coordinator of this site? Confirm its status | Lynchburg | United States | Unknown status |
| University of Wisconsin School of Medicine and Public Health (UWSMPH) Coordinator of this site? Confirm its status | Madison | United States | Unknown status |
| Gerogia Retina Coordinator of this site? Confirm its status | Marietta | United States | Unknown status |
| Florida Retina Institute Coordinator of this site? Confirm its status | Orlando | United States | Unknown status |
| Retina Specialty Institute Coordinator of this site? Confirm its status | Pensacola | United States | Unknown status |
| Retinal Research Institute, LLC Coordinator of this site? Confirm its status | Phoenix | United States | Unknown status |
| Eye Associates of Pinellas Coordinator of this site? Confirm its status | Pinellas Park | United States | Unknown status |
| Texas Retina Associates Coordinator of this site? Confirm its status | Plano | United States | Unknown status |
| Maine Eye Center Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
| Retina Consultants San Diego Coordinator of this site? Confirm its status | Poway | United States | Unknown status |
| Retina Consultants of Southern California Coordinator of this site? Confirm its status | Redlands | United States | Unknown status |
| Sierra Eye Associates Coordinator of this site? Confirm its status | Reno | United States | Unknown status |
| Retina Associates of Western NY, PC Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| Retinal Consultants Medical Group Coordinator of this site? Confirm its status | Sacramento | United States | Unknown status |
| Retina Associates of Utah Coordinator of this site? Confirm its status | Salt Lake City | United States | Unknown status |
| San Antonio Eye Center Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| Retinal Consultants of Texas Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| Retina Consultants PLLC Coordinator of this site? Confirm its status | Slingerlands | United States | Unknown status |
| Deep Blue Retina Clinical Research PLLC Coordinator of this site? Confirm its status | Southaven | United States | Unknown status |
| MedEye Associates Coordinator of this site? Confirm its status | South Miami | United States | Unknown status |
| Retina Partners of Northwest Arkansas Coordinator of this site? Confirm its status | Springdale | United States | Unknown status |
| New England Retina Consultants Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| The Retina Institute Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Retina Specialists of Tampa Coordinator of this site? Confirm its status | Tampa | United States | Unknown status |
| Retina Vitreous Associates of Florida Coordinator of this site? Confirm its status | Tampa | United States | Unknown status |
| NJ Retina Coordinator of this site? Confirm its status | Teaneck | United States | Unknown status |
| Retina Consultants of Texas Coordinator of this site? Confirm its status | The Woodlands | United States | Unknown status |
| NJ Retina Coordinator of this site? Confirm its status | Toms River | United States | Unknown status |
| Retina Specialists Coordinator of this site? Confirm its status | Towson | United States | Unknown status |
| Tulsa Retina Consultant Coordinator of this site? Confirm its status | Tulsa | United States | Unknown status |
| Tyler Retina Consultants Coordinator of this site? Confirm its status | Tyler | United States | Unknown status |
| Bay Area Retina Associates Coordinator of this site? Confirm its status | Walnut Creek | United States | Unknown status |
| Retina Group of New England, PC Coordinator of this site? Confirm its status | Waterford | United States | Unknown status |
| Salt Lake Retina Coordinator of this site? Confirm its status | West Jordan | United States | Unknown status |
| American Institute of Research Coordinator of this site? Confirm its status | Whittier | United States | Unknown status |
| Strategic Clinical Research Group, LLC Coordinator of this site? Confirm its status | Willow Park | United States | Unknown status |
| Cape Fear Retinal Associates, PC Coordinator of this site? Confirm its status | Wilmington | United States | Unknown status |
| Retina Associates, P.C. Coordinator of this site? Confirm its status | Winchester | United States | Unknown status |
| Piedmont Retina Specialists, P.A. - Winston-Salem Office Coordinator of this site? Confirm its status | Winston-Salem | United States | Unknown status |
| Center for Retina & Macular Disease Coordinator of this site? Confirm its status | Winter Haven | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.