NCT06672237Active, not recruitingPhase 3
A Phase 3 Study of NTLA-2001 in ATTRv-PN
MAGNITUDE-2: A Phase 3, Multinational, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of NTLA-2001 in Participants With Hereditary Transthyretin Amyloidosis With Polyneuropathy (ATTRv-PN)
Source: ClinicalTrials.gov · Last updated 5 Nov 2026
Brief summary (registry, in English)
This study will be conducted to evaluate the efficacy and safety of a single dose of nexiguran ziclumeran (NTLA-2001) compared to placebo in participants with ATTRv-PN.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 67 (actual)
- First submitted
- 1 Nov 2024
- Start date
- 22 Nov 2024
- Primary completion date
- Jul 2027
- Lead sponsor
- Intellia Therapeutics
- Diseases
- Amyloidosis
- NCT number
- NCT06672237
What you commit to
- Study type: Interventional · Phase 3
- Participants enrolled: 67
- From 22 Nov 2024 to the primary completion date, Jul 2027
- 14 sites in 6 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior receipt of a TTR silencer (Small interfering RNA (siRNA) or Antisense oligonucleotides (ASOs))
Other illness
- Diabetes mellitus
- New York Heart Association Class III or IV heart failure
- Liver failure
- Hepatitis B, hepatitis C or human immunodeficiency virus (HIV) infection
- History of liver disease
Other
- Other causes of amyloidosis (amyloidosis caused by non-TTR protein)
- Other known causes of sensorimotor or autonomic neuropathy
- Estimated Glomerular Filtration Rate \< 30 mL/min/1.73 m2
- Unable or unwilling to take vitamin A supplementation for the duration of the study
Who the study is looking for
- Diagnosis of ATTRv-PN
- Karnofsky Performance Status (KPS) ≥ 60
Age in the registry: 18 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (14)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital Italiano de Buenos Aires (HIBA) Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Hospital Britanico de Buenos Aires Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Hospital El Cruce Coordinator of this site? Confirm its status | San Juan Bautista | Argentina | Unknown status |
| Hospital das Clinicas da Universidade Estadual de Campinas UNICAMP Coordinator of this site? Confirm its status | Campinas | Brazil | Unknown status |
| HCFMRP - Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto Coordinator of this site? Confirm its status | Ribeirão Preto | Brazil | Unknown status |
| Instituto de Educacao Pesquisa e Gestao em Saude Coordinator of this site? Confirm its status | Rio de Janeiro | Brazil | Unknown status |
| PSEG Centro de Pesquisa Clinica S.A. Coordinator of this site? Confirm its status | São Paulo | Brazil | Unknown status |
| National Institute of Medical Sciences and Nutrition - Salvador Zubiran(INCMNSZ) Coordinator of this site? Confirm its status | Tlalpan | Mexico | Unknown status |
| Singapore General Hospital Coordinator of this site? Confirm its status | Singapore | Singapore | Unknown status |
| National University Hospital Coordinator of this site? Confirm its status | Singapore | Singapore | Unknown status |
| Siriraj Hospital Coordinator of this site? Confirm its status | Bangkok | Thailand | Unknown status |
| National Taiwan University Hospital Coordinator of this site? Confirm its status | Taipei | Taiwan | Unknown status |
| Taipei Veterans General Hospital Coordinator of this site? Confirm its status | Taipei | Taiwan | Unknown status |
| Chang Gung Medical Foundation-Linkou Branch Coordinator of this site? Confirm its status | Taoyuan | Taiwan | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.