NCT06676995Completed
Effects of Transcranial Pulse Stimulation in Parkinson's Disease
Parkinson's Disease: Overall Symptoms Improvement With Transcranial Pulse Stimulation (TPS)
Source: ClinicalTrials.gov · Last updated 10 Aug 2026
Brief summary (registry, in English)
The investigators are studying if Transcranial Pulse Stimulation (TPS) can improve various symptoms, including movement problems, thinking abilities, mood, fatigue, freezing while walking, voice quality, and issues with smell and taste. Previous research suggests TPS might help in Alzheimer's disease and could be helpful for Parkinson's as well. Investigators will check if TPS is safe, practical, and if it makes a noticeable difference in these symptoms compared to before the treatment.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 14 (actual)
- First submitted
- 4 Nov 2024
- Start date
- 31 Dec 2024
- Primary completion date
- 27 Jun 2025
- Lead sponsor
- Spaulding Rehabilitation Hospital
- Diseases
- Parkinson disease
- NCT number
- NCT06676995
What you commit to
- Study type: Interventional
- Participants enrolled: 14
- From 31 Dec 2024 to the primary completion date, 27 Jun 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Contraindications to transcranial brain stimulation (i.e., metal objects in the head, metal implanted brain medical devices, cortisone treatments within six weeks before the first stimulation session, central nervous system (CNS) thrombosis, etc).
- Contraindications to MRI according to Mass General Brigham screening in the Martinos Center (i.e., pacemaker, defibrillator or wires other than sternal wires, metallic foreign body in the eye, or drug infusion devices - if the models of these devices are not compatible with MRI).
Other illness
- Features suggestive of other causes of parkinsonism/Parkinson's-plus syndromes.
- History of deep brain stimulation, brain ablation surgeries, or malignant mass brain lesions.
- History of schizophrenia, bipolar illness, or alcohol/drug abuse within the past six months.
- Need for rapid clinical response due to conditions such as initiation, psychosis, or suicidality.
- Unstable medical conditions (e.g., uncontrolled diabetes, uncompensated cardiac issues, heart failure, uncompensated pulmonary disease, or chronic obstructive pulmonary disease).
- Epilepsy or disorders that significantly increase the likelihood of seizures, including: (i) severe traumatic brain injury; (ii) congenital birth defects leading to seizures; (iii) brain tumor; (iv) metabolic disorders associated with seizures; (v) intracranial or subarachnoid hemorrhage; and (vi) non-lacunar strokes.
Other
- Pregnancy.
- Bed- or wheelchair-bound patients.
Who the study is looking for
- Diagnosis of "probable" or "possible" Parkinson's Disease (PD), as defined by the current clinical criteria (52) or as confirmed by a co-investigator neurologist or confirmation via medical records or a letter from a patient's physician.
- Age from 40 to 90 years old.
- Disease stages 2 to 4 based on the UPDRS scale subdomain V (or Hoehn and Yahr scale).
- Taking stable medications for Parkinson's Disease for at least 30 days.
Age in the registry: 40 years to 90 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Spaulding Rehabilitation Hospital Coordinator of this site? Confirm its status | Cambridge | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.