NCT06678100Recruiting
Swallowing Impairments in Adults With and Without Alzheimer's Disease
Prevalence and Care Partner Burden of Individuals With Alzheimer's Disease
Source: ClinicalTrials.gov · Last updated 8 May 2026
Brief summary (registry, in English)
This research study is investigating whether people with Alzheimer's disease (AD) experience more changes to swallowing than their healthy age-matched peers. The prevalence of swallowing impairments in moderate-severe AD is high (85-93%), yet little is known about how swallow function evolves throughout the disease course in people with AD. The overall objective of this study is to evaluate swallowing function in adults with and without Alzheimer's disease. The investigator will also be involving the primary caregivers of individuals with Alzheimer's that are enrolled in the study to better understand the impact of swallowing impairments on the primary caregivers of those with Alzheimer's Disease. Healthy adults and individuals with Alzheimer's disease will: * undergo tests of cough and swallow function * undergo tests of grip and tongue strength * complete questionnaires Caregivers of individuals with Alzheimer's disease will also complete questionnaires.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 240 (estimated)
- First submitted
- 5 Nov 2024
- Start date
- 21 Apr 2025
- Primary completion date
- Feb 2027
- Lead sponsor
- Vanderbilt University Medical Center
- Diseases
- Alzheimer disease
- NCT number
- NCT06678100
What you commit to
- Study type: Observational
- Planned participants: 240
- From 21 Apr 2025 to the primary completion date, Feb 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Diagnosis of another type of dementia
- History of neurological/respiratory diseases
- History of head and neck surgery/head and neck cancer/radiation to head and neck region
- history of neurological disease
- history of respiratory disease
- history of head and neck surgery/head and neck cancer/radiation to head and neck region
- history of swallowing difficulties
Age
- individual \<60 years old
- individual \<60 years old
- Score \<25th percentile based on sex/age/education/race on the Montreal Cognitive Assessment (MOCA)
Other
- not consuming any oral intake
- Unable to follow basic directions
- Unable to provide consent based on the University of California, San Diego Brief Assessment of Capacity to Consent (UBACC), score \<15 OR provide assent and a legal guardian/health care decision maker provides consent.
- not the primary caregiver of an individual with AD
- unwilling to complete questionnaires/semi-structured interview
Who the study is looking for
- adult ≥60 years old
- diagnosis of AD by a neurologist (confirmed with imaging, spinal tap, behavioral testing)
- no prior history of other neurological diseases (aside from stroke which has resolved with no current symptoms)
- no prior history of respiratory diseases
- no prior history of head and neck surgery/head and neck cancer/radiation to head and neck region
- consuming some form of oral intake
- able to follow basic directions
- able/willing to provide consent/assent.
- care partner of an individual with AD
- willing to complete questionnaires/participate in an interview.
- adult ≥60 years old
- no prior history of neurological diseases (aside from stroke which has resolved with no current symptoms)
- no prior history of respiratory diseases
- 3\) no prior history of head and neck surgery/head and neck cancer/radiation to head and neck region 4) no prior history of swallowing difficulties based on participant report. 5) Score ≥25th percentile based on sex/age/education/race on the Montreal Cognitive Assessment (MOCA)
Age in the registry: 60 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Vanderbilt University Medical Center Coordinator of this site? Confirm its status | Nashville | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.