SHR-1701 Combined with SHR2554 and BP102 for MCRC

Prior treatment

• Prior treatment with immune checkpoint inhibitors;
• Received the following treatments before the first study treatment;
  • Major surgery within 28 days before treatment (tissue biopsy for diagnostic purposes is permitted).
  • Prior use of immunosuppressive medications, excluding nasal and inhaled corticosteroids or physiologic doses of systemic steroids (i.e., no more than 10 mg/d prednisone or equivalent pharmacologic doses of other corticosteroids) within 7 days before treatment;
  • Received immunomodulatory drugs within 3 weeks before treatment;
  • Received live attenuated vaccine within 28 days before treatment;
  • Receipt of other antitumor systemic therapy within 28 days prior to treatment;
• Within 6 months before enrollment, the following conditions: myocardial infarction, severe/unstable angina, NYHA class 2 or greater cardiac insufficiency, and clinically significant supraventricular or ventricular arrhythmia requiring clinical intervention; hypertension with poorly controlled by medications;
• Surgical treatment (except biopsy) within 6 weeks or unhealed surgical incision;
• A history of abdominal fistula, gastrointestinal perforation, intra-abdominal abscess, or active gastrointestinal bleeding within 6 months before the first study treatment

Other illness

• The patient has had other malignant tumors within 5 years (except cured basal cell carcinoma of the skin and carcinoma in situ of the cervix);
• Symptomatic brain or meningeal metastases (except for those whose BMS disease is stable for at least 4 weeks);
• Allergy to the study drug or any of its excipients;
• Presence of any active autoimmune disease or history of autoimmune disease with expected relapse;
• A known history of allogeneic organ transplantation or allogeneic hematopoietic stem cell transplantation
• Human immunodeficiency virus (HIV) infection or known AIDS, untreated active hepatitis, HBV-DNA ≥ 2500 IU/ml and abnormal liver function; hepatitis C or co-infection with hepatitis B and hepatitis C;
• A history of interstitial lung disease or non-infectious pneumonia, etc.;
• A history of severe bleeding within 3 months (\>30 ml at a time) or hemoptysis within 1 month (\>5 ml at a time) or a thromboembolic event (including pulmonary embolism, cerebral infarction, etc.) within 12 months;
• Imaging showing that the tumor has invaded a vital vascular perimeter or if, in the judgment of the investigator, the patient's tumor has a very high likelihood of invading a vital blood vessel and causing a fatal hemorrhage during therapy
• Unable to take the drug orally, or has a condition judged by the investigator to affect the absorption of the drug;
• Other conditions deemed by the investigator to be ineligible for inclusion in the study.

Other

• Long-standing unhealed wounds or fractures that have not healed properly
• Urine routine showed urine protein ≥2+, and 24-hour urine protein level \>1.0g;
• Pregnancy, lactation, and unwillingness of reproductively active subjects to use effective contraception;

• 18-75 years;
• Histological confirmed metastatic colorectal cancer;
• ECOG PS 0-1;
• At least one measurable lesion (according to RECIST1.1);
• Adequate hepatic, renal, coagulation, and hematologic functions;
• Agree to use contraception during the study and 3 months after the end of the study. Negative serum pregnancy test at screening for women of childbearing potential;
• Patients voluntarily enroll in the study.