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NCT06679946Enrolling by invitationPhase 3

A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

An Open-Label Extension Study to Assess the Safety and Efficacy of Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy (ATTR Amyloidosis With Cardiomyopathy)

Source: ClinicalTrials.gov · Last updated 21 Oct 2026

Brief summary (registry, in English)

The purpose of this study is to obtain safety, efficacy, and pharmacodynamic data on the use of vutrisiran in patients with ATTR amyloidosis with cardiomyopathy who continued on extended use of vutrisiran, or switched from patisiran.

Status (registry)
Enrolling by invitation
Phase (registry)
Phase 3
Study type
Interventional
Enrollment
700 (estimated)
First submitted
6 Nov 2024
Start date
3 Dec 2024
Primary completion date
31 Mar 2028
Lead sponsor
Alnylam Pharmaceuticals
Diseases
Amyloidosis
NCT number
NCT06679946
EudraCT number
2024-516568-27

What you commit to

  • Study type: Interventional · Phase 3
  • Planned participants: 700
  • From 3 Dec 2024 to the primary completion date, 31 Mar 2028
  • 73 sites in 17 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study design.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Has permanently discontinued study drug administration while participating in the parent studies, ALN-TTR02-011, ALN-TTR02-014, or ALN-TTRSC02-003
  • Future or current participation in another investigational device or drug study, scheduled to occur during this study

Other illness

  • Has other medical conditions or comorbidities which, in the opinion of the Investigator, would interfere with study compliance or data interpretation

Who the study is looking for

  • Patients who are participating in the patisiran parent studies ALN-TTR02-011 or ALN-TTR02-014 or who have completed the 24-month OLE Period in the vutrisiran parent study ALN-TTRSC02-003

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (73)

Sites in registry order. Save your city in your profile to sort them by distance.

SiteCityCountrySite status
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Buenos AiresArgentinaUnknown status
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CórdobaArgentinaUnknown status
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RosarioArgentinaUnknown status
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ViennaAustriaUnknown status
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AalstBelgiumUnknown status
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AnderlechtBelgiumUnknown status
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DendermondeBelgiumUnknown status
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GhentBelgiumUnknown status
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HasseltBelgiumUnknown status
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LeuvenBelgiumUnknown status
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LiègeBelgiumUnknown status
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RoeselareBelgiumUnknown status
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Ribeirão PretoBrazilUnknown status
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Rio de JaneiroBrazilUnknown status
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São PauloBrazilUnknown status
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PragueCzechiaUnknown status
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Aarhus NDenmarkUnknown status
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København ØDenmarkUnknown status
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Odense CDenmarkUnknown status
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BarcelonaSpainUnknown status
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BilbaoSpainUnknown status
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L'Hospitalet de LlobregatSpainUnknown status
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MadridSpainUnknown status
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MálagaSpainUnknown status
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CréteilFranceUnknown status
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MarseilleFranceUnknown status
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ParisFranceUnknown status
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RennesFranceUnknown status
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ToulouseFranceUnknown status
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BellshillUnited KingdomUnknown status
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BirminghamUnited KingdomUnknown status
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CardiffUnited KingdomUnknown status
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HexhamUnited KingdomUnknown status
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LondonUnited KingdomUnknown status
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ManchesterUnited KingdomUnknown status
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BolognaItalyUnknown status
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FlorenceItalyUnknown status
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PaviaItalyUnknown status
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SeoulSouth KoreaUnknown status
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GroningenNetherlandsUnknown status
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MaastrichtNetherlandsUnknown status
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UtrechtNetherlandsUnknown status
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OsloNorwayUnknown status
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CreixomilPortugalUnknown status
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LisbonPortugalUnknown status
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PortoPortugalUnknown status
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ViseuPortugalUnknown status
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GothenburgSwedenUnknown status
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SolnaSwedenUnknown status
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UmeåSwedenUnknown status
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TaipeiTaiwanUnknown status
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BaltimoreUnited StatesUnknown status
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Beverly HillsUnited StatesUnknown status
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BostonUnited StatesUnknown status
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ChicagoUnited StatesUnknown status
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ClevelandUnited StatesUnknown status
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ColumbusUnited StatesUnknown status
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DallasUnited StatesUnknown status
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DurhamUnited StatesUnknown status
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GlenviewUnited StatesUnknown status
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IndianapolisUnited StatesUnknown status
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Kansas CityUnited StatesUnknown status
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La JollaUnited StatesUnknown status
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NashvilleUnited StatesUnknown status
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New YorkUnited StatesUnknown status
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OmahaUnited StatesUnknown status
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PhiladelphiaUnited StatesUnknown status
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PhoenixUnited StatesUnknown status
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RochesterUnited StatesUnknown status
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Salt Lake CityUnited StatesUnknown status
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StanfordUnited StatesUnknown status
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St LouisUnited StatesUnknown status
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Washington D.C.United StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.