NCT06679985Active, not recruitingPhase 2
A Trial of Casdozokitug in Combination With Toripalimab Plus Bevacizumab in Participants With Unresectable and/or Locally Advanced or Metastatic Hepatocellular Carcinoma
A Randomized Phase 2 Study of Casdozokitug in Combination With Toripalimab Plus Bevacizumab in Participants With Unresectable and/or Locally Advanced or Metastatic Hepatocellular Carcinoma
Source: ClinicalTrials.gov · Last updated 15 Jul 2026
Brief summary (registry, in English)
The main goals of this study are to evaluate the safety and efficacy of casdozokitug in combination with toripalimab plus bevacizumab and to define a recommended dose for casdozokitug in combination with toripalimab plus bevacizumab.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 72 (estimated)
- First submitted
- 6 Nov 2024
- Start date
- 20 Dec 2024
- Primary completion date
- Sept 2027
- Lead sponsor
- Coherus Oncology, Inc.
- Diseases
- Liver and biliary tract cancer
- NCT number
- NCT06679985
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 72
- From 20 Dec 2024 to the primary completion date, Sept 2027
- 44 sites in 6 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Has received prior systemic therapy for HCC.
- Has previously received an anti-IL-27 antibody (Ab) or anti-IL-27-targeted therapy.
Other
- Has known fibrolamellar HCC histology, sarcomatoid HCC, or mixed cholangiocarcinoma and HCC.
- Has moderate or severe ascites.
- Has uncontrolled pleural effusion, pericardial effusion, or ascites requiring recurrent drainage procedures (once monthly or more frequently).
- Additional protocol-defined inclusion/exclusion criteria apply.
Who the study is looking for
- Unresectable locally advanced or metastatic HCC with diagnosis confirmed by histology/cytology or clinically by American Association for the Study of Liver Diseases criteria in cirrhotic participants.
- Disease that is not amenable to curative surgical and/or locoregional therapies or progressive disease (PD) after surgical and/or locoregional therapies.
- ≥ 1 measurable lesion (per RECIST v1.1) that is untreated.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (44)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Bankstown-Lidcombe Hospital Coordinator of this site? Confirm its status | Bankstown | Australia | Unknown status |
| St Vincent's Hospital Sydney Coordinator of this site? Confirm its status | Darlinghurst | Australia | Unknown status |
| Royal Brisbane and Women's Hospital Coordinator of this site? Confirm its status | Herston | Australia | Unknown status |
| Monash Health Coordinator of this site? Confirm its status | Melbourne | Australia | Unknown status |
| Linear Clinical Research Coordinator of this site? Confirm its status | Nedlands | Australia | Unknown status |
| Sunnybrook Health Sciences Centre - Bayview Campus Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| Princess Margaret Hospital Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| Humanity & Health Clinical Trial Centre Coordinator of this site? Confirm its status | Hong Kong | Hong Kong SAR China | Unknown status |
| Queen Mary Hospital Coordinator of this site? Confirm its status | Hong Kong | Hong Kong SAR China | Unknown status |
| Prince of Wales Hospital Coordinator of this site? Confirm its status | Shatin | Hong Kong SAR China | Unknown status |
| Curie Oncology Coordinator of this site? Confirm its status | Singapore | Singapore | Unknown status |
| Tan Tock Seng Hospital Coordinator of this site? Confirm its status | Singapore | Singapore | Unknown status |
| National Cancer Centre Singapore Coordinator of this site? Confirm its status | Singapore | Singapore | Unknown status |
| China Medical University Hospital Coordinator of this site? Confirm its status | Taichung | Taiwan | Unknown status |
| Chi Mei Medical Center Coordinator of this site? Confirm its status | Tainan | Taiwan | Unknown status |
| National Cheng Kung University Hospital Coordinator of this site? Confirm its status | Tainan | Taiwan | Unknown status |
| National Taiwan University Hospital Coordinator of this site? Confirm its status | Tainan | Taiwan | Unknown status |
| Taipei Veterans General Hospital Coordinator of this site? Confirm its status | Taipei | Taiwan | Unknown status |
| Linkou Chang Gung Memorial Hospital (CGMHLK) Coordinator of this site? Confirm its status | Taoyuan City | Taiwan | Unknown status |
| The Winship Cancer Institute Emory University Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
| Beverly Hills Cancer Center Coordinator of this site? Confirm its status | Beverly Hills | United States | Unknown status |
| Mountain States Tumor Institute at St. Luke's Regional Medical Center Coordinator of this site? Confirm its status | Boise | United States | Unknown status |
| University of North Carolina (UNC) - Chapel Hill Coordinator of this site? Confirm its status | Chapel Hill | United States | Unknown status |
| University Hospitals Cleveland Medical Center* Coordinator of this site? Confirm its status | Cleveland | United States | Unknown status |
| The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solovev Research Institute (OSUCCC - James) Coordinator of this site? Confirm its status | Columbus | United States | Unknown status |
| City of Hope Coordinator of this site? Confirm its status | Duarte | United States | Unknown status |
| Virginia Cancer Specialists Coordinator of this site? Confirm its status | Fairfax | United States | Unknown status |
| Prisma Health Cancer Institute Coordinator of this site? Confirm its status | Greenville | United States | Unknown status |
| City of Hope at Irvine Lennar Coordinator of this site? Confirm its status | Irvine | United States | Unknown status |
| University of Mississippi Medical Center Coordinator of this site? Confirm its status | Jackson | United States | Unknown status |
| Mayo Clinic- Jacksonville Coordinator of this site? Confirm its status | Jacksonville | United States | Unknown status |
| University of Kansas Cancer Center Coordinator of this site? Confirm its status | Kansas City | United States | Unknown status |
| Cancer & Blood Specialty Clinic Coordinator of this site? Confirm its status | Lakewood | United States | Unknown status |
| USC / Norris Comprehensive Cancer Center Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| UofL Health Brown Cancer Center Coordinator of this site? Confirm its status | Louisville | United States | Unknown status |
| UW Carbone Cancer Center - Cancer Connect Coordinator of this site? Confirm its status | Madison | United States | Unknown status |
| David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Virginia Oncology Associates Coordinator of this site? Confirm its status | Norfolk | United States | Unknown status |
| University of Pittsburgh Medical Center (UPMC) - Hillman Cancer Center Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
| Christus St. Vincent Regional Medical Center Coordinator of this site? Confirm its status | Santa Fe | United States | Unknown status |
| Sarcoma Oncology Center Coordinator of this site? Confirm its status | Santa Monica | United States | Unknown status |
| Mayo Clinic Scottsdale Coordinator of this site? Confirm its status | Scottsdale | United States | Unknown status |
| Montefiore Medical Center Coordinator of this site? Confirm its status | The Bronx | United States | Unknown status |
| University of Arizona Cancer Center Coordinator of this site? Confirm its status | Tucson | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.