NCT06682260CompletedPhase 4
Evaluating the Effects of Nitroglycerin on Heart Function and Urinary Output in Patients With Acute Heart Failure
Impact of Nitroglycerin-induced Vasodilation on Stroke Volume and Diuretic Response in Acute Heart Failure: A Protocol for a Mechanistic Trial
Source: ClinicalTrials.gov · Last updated 18 Mar 2026
Brief summary (registry, in English)
This study aims to understand how nitroglycerin affects patients with acute heart failure, a condition where the heart struggles to pump blood effectively, leading to fluid buildup and breathing difficulties. Nitroglycerin relaxes blood vessels to ease the heart's workload and may help reduce fluid buildup. The investigators hypothesize that nitroglycerin can increase blood flow from the heart and promote urine production, which may reduce congestion in AHF patients. By studying heart function, blood volume, and fluid levels during treatment, the goal is to identify which patients may benefit most from nitroglycerin therapy.
- Status (registry)
- Completed
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 21 (actual)
- First submitted
- 7 Nov 2024
- Start date
- 1 Feb 2025
- Primary completion date
- 30 Nov 2025
- Lead sponsor
- Copenhagen University Hospital, Hvidovre
- Diseases
- Heart failure, Stroke
- NCT number
- NCT06682260
What you commit to
- Study type: Interventional · Phase 4
- Participants enrolled: 21
- From 1 Feb 2025 to the primary completion date, 30 Nov 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Ongoing ventricular taky- or brady-arrythmias or supraventricular arrhythmias with heart rate \> 180 or \< 40 bpm.
- Recent myocardial infarction or thromboembolic events.
Other
- Retinopathy or intraocular lens implantation (contraindication to Valsalva maneuver)
- Intake of sildenafil or vardenafil withing 24 h and tadalafil within 48 h.
- Absolute contraindication for vasodilation using nitroglycerin as assessed by treating physician
- Intravenous administration of furosemide within 2 hours of baseline measurements
Who the study is looking for
- Age ≥ 18 years
- Clinical diagnosis of AHF requiring hospitalization
- Systolic blood pressure ≥85 mmHg
- Echocardiographic signs of cardiac dysfunction, by at least one of
- Left ventricular ejection fraction ≤45%
- Abnormal left ventricular filling with dilatation of the left atrium
- Elevated filling pressures (systolic pulmonary artery pressure\>30, dilated vena cava inferior or E/é\>10)
- Significant left-sided heart valve disease
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hvidovre Hospital Coordinator of this site? Confirm its status | Copenhagen | Denmark | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.