NCT06682663Completed
Impact of Live Streaming Exercise on Liver Health in MASLD Pregnant Women
Evaluation of the Effect of Live Streaming Exercise on the Improvement of Hepatic Steatosis and Fibrosis in Pregnant Women With MASLD and Its Study Based on the Liver-gut Axis Mechanism.
Source: ClinicalTrials.gov · Last updated 20 Oct 2026
Brief summary (registry, in English)
Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) is a clinical and pathological syndrome characterized primarily by excessive intracellular fat accumulation in the liver, excluding alcohol-related and other specific causes. Recent research has identified an association between MASLD and an increased risk of pregnancy-related complications and adverse pregnancy outcomes, including gestational diabetes, preeclampsia, preterm birth, and large-for-gestational-age infants. MASLD in pregnant women poses multiple risks to maternal and infant health. Regular physical exercise during pregnancy has been shown to effectively reduce the incidence of pregnancy complications and adverse outcomes, while also alleviating hepatic steatosis and fibrosis. This study is a randomized controlled trial aimed at exploring the feasibility and effectiveness of online exercise interventions for pregnant women with MASLD, as well as conducting a cost-effectiveness analysis and investigating the underlying physiological mechanisms based on the liver-gut axis. The findings are intended to provide scientific evidence and practical recommendations for managing pregnancy health and intervening in MASLD during pregnancy.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 220 (actual)
- First submitted
- 6 Nov 2024
- Start date
- 18 Nov 2024
- Primary completion date
- 31 May 2026
- Lead sponsor
- Peking University
- Diseases
- Fatty liver disease (MASLD/MASH)
- NCT number
- NCT06682663
What you commit to
- Study type: Interventional
- Participants enrolled: 220
- From 18 Nov 2024 to the primary completion date, 31 May 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current or previous use of drugs that affect body weight (such as hormones);
- Any previous medication for hypertension, diabetes, heart disease, kidney disease, systemic lupus erythematosus, thyroid disease or mental illness;
Other illness
- History of threatened abortion;
- Patients with chronic hepatitis virus or other chronic liver diseases, excluding MASLD;
Other
- Cervical length ≤ 25 mm;
- Exercise contraindications or doctor advice not to exercise during pregnancy;
- Non-natural conception or infertility treatment;
- Participating in other pregnancy intervention research projects.
Who the study is looking for
- Singleton pregnancy;
- Gestational age ≤10-13+6 weeks at enrollment;
- Age between 20 and 45 years;
- Patients diagnosed with MASLD;
- Signed informed consent.
Age in the registry: 20 years to 45 years · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Beijing Friendship Hospital, Capital Medical University Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.