A Study to Investigate Weight Management With LY3549492 Compared With Placebo in Adult Participants With Obesity or Overweight

Prior treatment

• Have a prior or planned surgical treatment for obesity, except prior liposuction or abdominoplasty, if performed \>1 year prior to screening.
• Have any of the following cardiovascular conditions within 3 months prior to screening:
  • acute myocardial infarction
  • cerebrovascular accident (stroke)
  • unstable angina, or
  • hospitalization due to congestive heart failure.

Other illness

• Have Type 2 Diabetes Mellitus or Type 1 Diabetes Mellitus
• Have a history of acute or chronic pancreatitis
• Have renal impairment
• Have type 1 diabetes mellitus, latent autoimmune diabetes in adults, or history of ketoacidosis or hyperosmolar coma.
• Have poorly controlled hypertension.
• Have signs and symptoms of any liver disease other than nonalcoholic fatty liver disease.
• Have a history of symptomatic gallbladder disease within the past 2 years
• Have a lifetime history of suicide attempts.

Other

• W8M-MC-GN01:
• Individuals who are of childbearing potential
  • W8M-MC-CWMM:

• W8M-MC-GN01:
• Assigned male at birth
• Assigned female at birth, who are of non-childbearing potential
  • W8M-MC-CWMM:
• Have a BMI of
  • ≥ 30 kilograms per square meter (kg/m²) or
  • ≥ 27 kg/m² and \< 30 kg/m² with at least one weight-related comorbidity
• Have had a stable body weight for the 3 months prior to randomization (\<5% body weight gain and/or loss)