NCT06683742Active, not recruitingPhase 3
A 2-year Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD) (LUCIA) Primary Efficacy Will be Determined at Week 56
A 2-year Phase 3, Multicenter, Prospective, Randomized, Double-Masked, Parallel-Group Study of EYP-1901, a Tyrosine Kinase Inhibitor (TKI), Compared to Aflibercept in Subjects With Wet AMD
Source: ClinicalTrials.gov · Last updated 3 Sept 2026
Brief summary (registry, in English)
This is a phase 3 randomized, double -masked study comparing the efficacy of EYP-1901 against Aflibercept.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 400 (estimated)
- First submitted
- 8 Nov 2024
- Start date
- 27 Nov 2024
- Primary completion date
- Oct 2026
- Lead sponsor
- EyePoint Pharmaceuticals, Inc.
- Diseases
- Macular degeneration
- NCT number
- NCT06683742
- EU CT number
- 2024-518030-83-00
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 400
- From 27 Nov 2024 to the primary completion date, Oct 2026
- 133 sites in 10 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Subfoveal fibrosis, atrophy, or scarring in the center subfield.
- BCVA using ETDRS charts \<20 letters (20/400 Snellen equivalent) in the fellow eye.
Who the study is looking for
- Previously treated or treatment naïve patients with a documented diagnosis of wAMD in the study eye, with onset of disease that began at any time prior to the Screening Visit.
- Best Corrected Visual Acuity (BCVA) by Early Treatment Diabetic Retinopathy Study (ETDRS) letter score between 78 to 35 letters (approximately 20/32 to 20/200 Snellen equivalent) in the study eye at the Screening Visit and on Baseline (Day 1).
- For previously-treated subjects, must have been treated with at least 2 anti-VEGF IVT injections (i.e., aflibercept 2 mg, aflibercept 8 mg, bevacizumab, ranibizumab, or faricimab) in the previous 6 months for wAMD per standard of care in the study eye prior to the Screening Visit.
Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers
Sites (133)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Retina Prime at Jardim Europa Medical Center Coordinator of this site? Confirm its status | Aracaju | Brazil | Unknown status |
| Centro Brasileiro de Pesquisa Clinica - Blumenau Coordinator of this site? Confirm its status | Blumenau | Brazil | Unknown status |
| Hospital de Olhos Oeste Paulista Coordinator of this site? Confirm its status | São Paulo | Brazil | Unknown status |
| Clínica Oftalmológica São Lucas - Retina Clinic Coordinator of this site? Confirm its status | São Paulo | Brazil | Unknown status |
| Hospital Oftalmológico de Sorocaba (Centro de Estudos) Coordinator of this site? Confirm its status | Sorocaba | Brazil | Unknown status |
| VISUS, spol s.r.o. Coordinator of this site? Confirm its status | Náchod | Czechia | Active, not recruiting |
| Fakultni nemocnice Ostrava Coordinator of this site? Confirm its status | Ostrava | Czechia | Active, not recruiting |
| Vseobecna fakultni nemocnice v Praze Coordinator of this site? Confirm its status | Prague | Czechia | Active, not recruiting |
| Fakultni nemocnice Kralovske Vinohrady Coordinator of this site? Confirm its status | Prague | Czechia | Active, not recruiting |
| Axon Clinical s.r.o. Coordinator of this site? Confirm its status | Prague 5 | Czechia | Active, not recruiting |
| Medical Private Care s.r.o. Coordinator of this site? Confirm its status | Sokolov | Czechia | Active, not recruiting |
| Charite Universitaetsmedizin Berlin KöR Coordinator of this site? Confirm its status | Berlin | Germany | Active, not recruiting |
| St. Elisabeth Krankenhaus GmbH Coordinator of this site? Confirm its status | Cologne | Germany | Active, not recruiting |
| Technische Universitaet Dresden Coordinator of this site? Confirm its status | Dresden | Germany | Active, not recruiting |
| Medical Center- University of Freiburg Coordinator of this site? Confirm its status | Freiburg im Breisgau | Germany | Active, not recruiting |
| Klinikum der Stadt Ludwigshafen am Rhein gGmbH Coordinator of this site? Confirm its status | Ludwigshafen Am Rhein | Germany | Active, not recruiting |
| Imperial College Healthcare NHS Trust Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| Budapesti Jahn Ferenc Del-pesti Korhaz es Rendelointezet Coordinator of this site? Confirm its status | Budapest | Hungary | Active, not recruiting |
| Budapesti Bajcsy-Zsilinszky Korhaz Es Rendelointezet Coordinator of this site? Confirm its status | Budapest | Hungary | Active, not recruiting |
| Central Hospital Of Northern Pest Military Hospital Coordinator of this site? Confirm its status | Budapest VI | Hungary | Active, not recruiting |
| Semmelweis University Coordinator of this site? Confirm its status | Budapest VIII | Hungary | Active, not recruiting |
| Budapest Retina Associates Kft. Coordinator of this site? Confirm its status | Budapest XIII | Hungary | Active, not recruiting |
| University of Debrecen Coordinator of this site? Confirm its status | Debrecen | Hungary | Active, not recruiting |
| University of Pecs Coordinator of this site? Confirm its status | Pécs | Hungary | Active, not recruiting |
| Nozologen Kft. Coordinator of this site? Confirm its status | Pécs | Hungary | Active, not recruiting |
| University of Szeged Coordinator of this site? Confirm its status | Szeged | Hungary | Active, not recruiting |
| Zala Varmegyei Szent Rafael Korhaz Coordinator of this site? Confirm its status | Zalaegerszeg | Hungary | Active, not recruiting |
| Shamir Medical Center Ophthalmology Out Patient Clinic Coordinator of this site? Confirm its status | Be’er Ya‘aqov | Israel | Unknown status |
| Bnai Zion Medical Center Coordinator of this site? Confirm its status | Haifa | Israel | Unknown status |
| Carmel Medical Center Coordinator of this site? Confirm its status | Haifa | Israel | Unknown status |
| Meir Medical Center Ophthalmology Department Coordinator of this site? Confirm its status | Kfar Saba | Israel | Unknown status |
| Rabin Medical Center Coordinator of this site? Confirm its status | Petah Tikva | Israel | Unknown status |
| Kaplan Medical Center Coordinator of this site? Confirm its status | Rehovot | Israel | Unknown status |
| The Tel-Aviv Sourasky Medical Centre Coordinator of this site? Confirm its status | Tel Aviv | Israel | Unknown status |
| Rising Retina Clinic Coordinator of this site? Confirm its status | Ahmedabad | India | Unknown status |
| Netralayam VIP Coordinator of this site? Confirm its status | Kolkata | India | Unknown status |
| Shanti Saroj Netralay Coordinator of this site? Confirm its status | Miraj | India | Unknown status |
| Shroff Eye Hospital Coordinator of this site? Confirm its status | Mumbai | India | Unknown status |
| K. B. Haji Bachooali Charitable Ophthalmic & E.N.T. Hospital Coordinator of this site? Confirm its status | Mumbai | India | Unknown status |
| Netrodaya - The Eye City Coordinator of this site? Confirm its status | Varanasi | India | Unknown status |
| OFTALMIKA Sp. z o.o Coordinator of this site? Confirm its status | Bydgoszcz | Poland | Active, not recruiting |
| Szpital Sw. Rozy Sp. z o.o. Coordinator of this site? Confirm its status | Cracow | Poland | Active, not recruiting |
| Mackiewicz Okulistyka Sp. z o.o. Coordinator of this site? Confirm its status | Lublin | Poland | Active, not recruiting |
| Centrum Diagnostyki i Mikrochirurgii Oka-Lens Sp. z o.o. Coordinator of this site? Confirm its status | Olsztyn | Poland | Active, not recruiting |
| Centrum Medyczne Uno-Med Sp. z o.o. Coordinator of this site? Confirm its status | Tarnow | Poland | Active, not recruiting |
| Centrum Medyczne Piasta 47 Sp. z o.o. Coordinator of this site? Confirm its status | Walbrzych | Poland | Active, not recruiting |
| Warszawski Szpital Okulistyczny Sp. z o.o. Coordinator of this site? Confirm its status | Warsaw | Poland | Active, not recruiting |
| F D Roosevelt University General Hospital Of Banska Bystrica Coordinator of this site? Confirm its status | Banska Bystrica | Slovakia | Active, not recruiting |
| Robin Look spol. s r.o. Coordinator of this site? Confirm its status | Bratislava | Slovakia | Active, not recruiting |
| University Hospital Bratislava Coordinator of this site? Confirm its status | Bratislava | Slovakia | Active, not recruiting |
| 3 F s.r.o. Coordinator of this site? Confirm its status | Kosice | Slovakia | Active, not recruiting |
| Fakultna Nemocnica Nitra Coordinator of this site? Confirm its status | Nitra | Slovakia | Active, not recruiting |
| Euromedix a.s. Coordinator of this site? Confirm its status | Petrzalka | Slovakia | Active, not recruiting |
| Nemocnica Poprad, a.s. Coordinator of this site? Confirm its status | Poprad | Slovakia | Active, not recruiting |
| Nemocnica s poliklinikou Trebisov a.s. Coordinator of this site? Confirm its status | Trebišov | Slovakia | Active, not recruiting |
| Panhandle Eye Group, LLP. - Southwest Retina Specialists Coordinator of this site? Confirm its status | Amarillo | United States | Unknown status |
| Win Retina Coordinator of this site? Confirm its status | Arcadia | United States | Unknown status |
| Texas Retina Associates Coordinator of this site? Confirm its status | Arlington | United States | Unknown status |
| Austin Clinical Research, LLC Coordinator of this site? Confirm its status | Austin | United States | Unknown status |
| Austin Research Center for Retina Coordinator of this site? Confirm its status | Austin | United States | Unknown status |
| Austin Retina Associates Coordinator of this site? Confirm its status | Austin | United States | Unknown status |
| Pacific Northwest Retina Coordinator of this site? Confirm its status | Bellevue | United States | Unknown status |
| Wills Eye Physician Mid Atlantic Retina Coordinator of this site? Confirm its status | Bethlehem | United States | Unknown status |
| Doctor Retina, PC Coordinator of this site? Confirm its status | Beverly Hills | United States | Unknown status |
| Envision Ocular, LLC Coordinator of this site? Confirm its status | Bloomfield | United States | Unknown status |
| Gailey Eye Clinic Coordinator of this site? Confirm its status | Bloomington | United States | Unknown status |
| Star Vision Research Coordinator of this site? Confirm its status | Burleson | United States | Unknown status |
| AVRUC Coordinator of this site? Confirm its status | Carmel | United States | Unknown status |
| NC Retina Associates - Cary Research Coordinator of this site? Confirm its status | Cary | United States | Unknown status |
| Mid Atlantic Retina Coordinator of this site? Confirm its status | Cherry Hill | United States | Unknown status |
| Blue Ocean Clinical Research Coordinator of this site? Confirm its status | Clearwater | United States | Unknown status |
| Retina Consultants of Southern Colorado Coordinator of this site? Confirm its status | Colorado Springs | United States | Unknown status |
| Connecticut Eye Consultants, P.C. Coordinator of this site? Confirm its status | Danbury | United States | Unknown status |
| Rand Eye Institute Coordinator of this site? Confirm its status | Deerfield Beach | United States | Unknown status |
| RSC Research, PLLC Coordinator of this site? Confirm its status | Denver | United States | Unknown status |
| NJ Retina Coordinator of this site? Confirm its status | Edison | United States | Unknown status |
| Retina Vitreous Center, PLLC Coordinator of this site? Confirm its status | Edmond | United States | Unknown status |
| Retina Associates Coordinator of this site? Confirm its status | Elmhurst | United States | Unknown status |
| The Retina Partners Coordinator of this site? Confirm its status | Encino | United States | Unknown status |
| Eye Center of Northern Colorado, PC Coordinator of this site? Confirm its status | Fort Collins | United States | Unknown status |
| Retina Group of Florida Coordinator of this site? Confirm its status | Fort Lauderdale | United States | Unknown status |
| RCOC Clinical Research Institute Inc. Coordinator of this site? Confirm its status | Fullerton | United States | Unknown status |
| Associated Retina Consultans Coordinator of this site? Confirm its status | Gilbert | United States | Unknown status |
| Global Research Management, Inc Coordinator of this site? Confirm its status | Glendale | United States | Unknown status |
| Retina Associates of Michigan Coordinator of this site? Confirm its status | Grand Blanc | United States | Unknown status |
| SightSera Clinical Research LLC Coordinator of this site? Confirm its status | Greenwich | United States | Unknown status |
| Mid Atlantic Retina Specialists Coordinator of this site? Confirm its status | Hagerstown | United States | Unknown status |
| Cumberland Valley Retina Consultants Coordinator of this site? Confirm its status | Hagerstown | United States | Unknown status |
| Graystone Eye - Hickory Office Coordinator of this site? Confirm its status | Hickory | United States | Unknown status |
| Berkeley Eye Center Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| Atlantis Eyecare Coordinator of this site? Confirm its status | Huntington Beach | United States | Unknown status |
| Retina Consultants of Texas Coordinator of this site? Confirm its status | Katy | United States | Unknown status |
| Colorado Retina Associates Coordinator of this site? Confirm its status | Lakewood | United States | Unknown status |
| The Eye Institute of West Florida Coordinator of this site? Confirm its status | Largo | United States | Unknown status |
| Retina Associates of Kentucky Coordinator of this site? Confirm its status | Lexington | United States | Unknown status |
| Retina Vitreous Surgeons of CNY, PC Coordinator of this site? Confirm its status | Liverpool | United States | Unknown status |
| South Coast Retina Center Coordinator of this site? Confirm its status | Long Beach | United States | Unknown status |
| The Eye Care Institute Coordinator of this site? Confirm its status | Louisville | United States | Unknown status |
| Valley Retina Institute P.A. Coordinator of this site? Confirm its status | McAllen | United States | Unknown status |
| Retina Associates New Orleans Coordinator of this site? Confirm its status | Metairie | United States | Unknown status |
| Retinal Consultants Medical Group Coordinator of this site? Confirm its status | Modesto | United States | Unknown status |
| Northern California Retina Vitreous Associates Medical Group INC. Coordinator of this site? Confirm its status | Mountain View | United States | Unknown status |
| Tennessee Retina Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
| NYC Retina Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Kaiser Permanente Coordinator of this site? Confirm its status | Oakland | United States | Unknown status |
| Illinois Retina Associates, S.C. Coordinator of this site? Confirm its status | Oak Park | United States | Unknown status |
| California Retina Consultants Oxnard Office Coordinator of this site? Confirm its status | Oxnard | United States | Unknown status |
| Retina Care Specialists Coordinator of this site? Confirm its status | Palm Beach Gardens | United States | Unknown status |
| Phoenix Retina Clinical Trials, LLC Coordinator of this site? Confirm its status | Phoenix | United States | Unknown status |
| Associated Retina Consultants - Phoenix Coordinator of this site? Confirm its status | Phoenix | United States | Unknown status |
| 3RP/ Windy City Retina Coordinator of this site? Confirm its status | Plainfield | United States | Unknown status |
| Texas Retina Associates Coordinator of this site? Confirm its status | Plano | United States | Unknown status |
| Fort Lauderdale Eye Institute Coordinator of this site? Confirm its status | Plantation | United States | Unknown status |
| Black Hills Regional Eye Institute Coordinator of this site? Confirm its status | Rapid City | United States | Unknown status |
| California Eye Specialists Medical Group, Inc. Coordinator of this site? Confirm its status | Redlands | United States | Unknown status |
| Retina Consultants of Southern California Coordinator of this site? Confirm its status | Redlands | United States | Unknown status |
| Retina Associates of Western NY, PC Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| VRMG Inc Coordinator of this site? Confirm its status | Sacramento | United States | Unknown status |
| Retina Associates of South Texas Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| TX RCTX Retina Consultants of Texas Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| Retina Macula Institute of Arizona Coordinator of this site? Confirm its status | Scottsdale | United States | Unknown status |
| MedEye Associates Coordinator of this site? Confirm its status | South Miami | United States | Unknown status |
| Cascade Medical Research lnstitute, LLC Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Retina Vitreous Associates of Florida - Saint Petersburg Coordinator of this site? Confirm its status | St. Petersburg | United States | Unknown status |
| East Florida Eye Institute Coordinator of this site? Confirm its status | Stuart | United States | Unknown status |
| Retina Specialists of Tampa Coordinator of this site? Confirm its status | Tampa | United States | Unknown status |
| Tyler Retina Consultants Coordinator of this site? Confirm its status | Tyler | United States | Unknown status |
| North Carolina Retina Associates Coordinator of this site? Confirm its status | Wake Forest | United States | Unknown status |
| Bay Area Retina Associates Coordinator of this site? Confirm its status | Walnut Creek | United States | Unknown status |
| Virginia Retina Center Coordinator of this site? Confirm its status | Warrenton | United States | Unknown status |
| VRCNY/Long Island Vitreoretinal Consultants Coordinator of this site? Confirm its status | Westbury | United States | Unknown status |
| Haik Humble Eye Center Coordinator of this site? Confirm its status | West Monroe | United States | Unknown status |
| Vitreo-Retinal Associates, PC Coordinator of this site? Confirm its status | Worcester | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.