Fact CheckerSign in

NCT06683742Active, not recruitingPhase 3

A 2-year Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD) (LUCIA) Primary Efficacy Will be Determined at Week 56

A 2-year Phase 3, Multicenter, Prospective, Randomized, Double-Masked, Parallel-Group Study of EYP-1901, a Tyrosine Kinase Inhibitor (TKI), Compared to Aflibercept in Subjects With Wet AMD

Source: ClinicalTrials.gov · Last updated 3 Sept 2026

Brief summary (registry, in English)

This is a phase 3 randomized, double -masked study comparing the efficacy of EYP-1901 against Aflibercept.

Status (registry)
Active, not recruiting
Phase (registry)
Phase 3
Study type
Interventional
Enrollment
400 (estimated)
First submitted
8 Nov 2024
Start date
27 Nov 2024
Primary completion date
Oct 2026
Lead sponsor
EyePoint Pharmaceuticals, Inc.
NCT number
NCT06683742
EU CT number
2024-518030-83-00

What you commit to

  • Study type: Interventional · Phase 3
  • Planned participants: 400
  • From 27 Nov 2024 to the primary completion date, Oct 2026
  • 133 sites in 10 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other

  • Subfoveal fibrosis, atrophy, or scarring in the center subfield.
  • BCVA using ETDRS charts \<20 letters (20/400 Snellen equivalent) in the fellow eye.

Who the study is looking for

  • Previously treated or treatment naïve patients with a documented diagnosis of wAMD in the study eye, with onset of disease that began at any time prior to the Screening Visit.
  • Best Corrected Visual Acuity (BCVA) by Early Treatment Diabetic Retinopathy Study (ETDRS) letter score between 78 to 35 letters (approximately 20/32 to 20/200 Snellen equivalent) in the study eye at the Screening Visit and on Baseline (Day 1).
  • For previously-treated subjects, must have been treated with at least 2 anti-VEGF IVT injections (i.e., aflibercept 2 mg, aflibercept 8 mg, bevacizumab, ranibizumab, or faricimab) in the previous 6 months for wAMD per standard of care in the study eye prior to the Screening Visit.

Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (133)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Retina Prime at Jardim Europa Medical Center
Coordinator of this site? Confirm its status
AracajuBrazilUnknown status
Centro Brasileiro de Pesquisa Clinica - Blumenau
Coordinator of this site? Confirm its status
BlumenauBrazilUnknown status
Hospital de Olhos Oeste Paulista
Coordinator of this site? Confirm its status
São PauloBrazilUnknown status
Clínica Oftalmológica São Lucas - Retina Clinic
Coordinator of this site? Confirm its status
São PauloBrazilUnknown status
Hospital Oftalmológico de Sorocaba (Centro de Estudos)
Coordinator of this site? Confirm its status
SorocabaBrazilUnknown status
VISUS, spol s.r.o.
Coordinator of this site? Confirm its status
NáchodCzechiaActive, not recruiting
Fakultni nemocnice Ostrava
Coordinator of this site? Confirm its status
OstravaCzechiaActive, not recruiting
Vseobecna fakultni nemocnice v Praze
Coordinator of this site? Confirm its status
PragueCzechiaActive, not recruiting
Fakultni nemocnice Kralovske Vinohrady
Coordinator of this site? Confirm its status
PragueCzechiaActive, not recruiting
Axon Clinical s.r.o.
Coordinator of this site? Confirm its status
Prague 5CzechiaActive, not recruiting
Medical Private Care s.r.o.
Coordinator of this site? Confirm its status
SokolovCzechiaActive, not recruiting
Charite Universitaetsmedizin Berlin KöR
Coordinator of this site? Confirm its status
BerlinGermanyActive, not recruiting
St. Elisabeth Krankenhaus GmbH
Coordinator of this site? Confirm its status
CologneGermanyActive, not recruiting
Technische Universitaet Dresden
Coordinator of this site? Confirm its status
DresdenGermanyActive, not recruiting
Medical Center- University of Freiburg
Coordinator of this site? Confirm its status
Freiburg im BreisgauGermanyActive, not recruiting
Klinikum der Stadt Ludwigshafen am Rhein gGmbH
Coordinator of this site? Confirm its status
Ludwigshafen Am RheinGermanyActive, not recruiting
Imperial College Healthcare NHS Trust
Coordinator of this site? Confirm its status
LondonUnited KingdomUnknown status
Budapesti Jahn Ferenc Del-pesti Korhaz es Rendelointezet
Coordinator of this site? Confirm its status
BudapestHungaryActive, not recruiting
Budapesti Bajcsy-Zsilinszky Korhaz Es Rendelointezet
Coordinator of this site? Confirm its status
BudapestHungaryActive, not recruiting
Central Hospital Of Northern Pest Military Hospital
Coordinator of this site? Confirm its status
Budapest VIHungaryActive, not recruiting
Semmelweis University
Coordinator of this site? Confirm its status
Budapest VIIIHungaryActive, not recruiting
Budapest Retina Associates Kft.
Coordinator of this site? Confirm its status
Budapest XIIIHungaryActive, not recruiting
University of Debrecen
Coordinator of this site? Confirm its status
DebrecenHungaryActive, not recruiting
University of Pecs
Coordinator of this site? Confirm its status
PécsHungaryActive, not recruiting
Nozologen Kft.
Coordinator of this site? Confirm its status
PécsHungaryActive, not recruiting
University of Szeged
Coordinator of this site? Confirm its status
SzegedHungaryActive, not recruiting
Zala Varmegyei Szent Rafael Korhaz
Coordinator of this site? Confirm its status
ZalaegerszegHungaryActive, not recruiting
Shamir Medical Center Ophthalmology Out Patient Clinic
Coordinator of this site? Confirm its status
Be’er Ya‘aqovIsraelUnknown status
Bnai Zion Medical Center
Coordinator of this site? Confirm its status
HaifaIsraelUnknown status
Carmel Medical Center
Coordinator of this site? Confirm its status
HaifaIsraelUnknown status
Meir Medical Center Ophthalmology Department
Coordinator of this site? Confirm its status
Kfar SabaIsraelUnknown status
Rabin Medical Center
Coordinator of this site? Confirm its status
Petah TikvaIsraelUnknown status
Kaplan Medical Center
Coordinator of this site? Confirm its status
RehovotIsraelUnknown status
The Tel-Aviv Sourasky Medical Centre
Coordinator of this site? Confirm its status
Tel AvivIsraelUnknown status
Rising Retina Clinic
Coordinator of this site? Confirm its status
AhmedabadIndiaUnknown status
Netralayam VIP
Coordinator of this site? Confirm its status
KolkataIndiaUnknown status
Shanti Saroj Netralay
Coordinator of this site? Confirm its status
MirajIndiaUnknown status
Shroff Eye Hospital
Coordinator of this site? Confirm its status
MumbaiIndiaUnknown status
K. B. Haji Bachooali Charitable Ophthalmic & E.N.T. Hospital
Coordinator of this site? Confirm its status
MumbaiIndiaUnknown status
Netrodaya - The Eye City
Coordinator of this site? Confirm its status
VaranasiIndiaUnknown status
OFTALMIKA Sp. z o.o
Coordinator of this site? Confirm its status
BydgoszczPolandActive, not recruiting
Szpital Sw. Rozy Sp. z o.o.
Coordinator of this site? Confirm its status
CracowPolandActive, not recruiting
Mackiewicz Okulistyka Sp. z o.o.
Coordinator of this site? Confirm its status
LublinPolandActive, not recruiting
Centrum Diagnostyki i Mikrochirurgii Oka-Lens Sp. z o.o.
Coordinator of this site? Confirm its status
OlsztynPolandActive, not recruiting
Centrum Medyczne Uno-Med Sp. z o.o.
Coordinator of this site? Confirm its status
TarnowPolandActive, not recruiting
Centrum Medyczne Piasta 47 Sp. z o.o.
Coordinator of this site? Confirm its status
WalbrzychPolandActive, not recruiting
Warszawski Szpital Okulistyczny Sp. z o.o.
Coordinator of this site? Confirm its status
WarsawPolandActive, not recruiting
F D Roosevelt University General Hospital Of Banska Bystrica
Coordinator of this site? Confirm its status
Banska BystricaSlovakiaActive, not recruiting
Robin Look spol. s r.o.
Coordinator of this site? Confirm its status
BratislavaSlovakiaActive, not recruiting
University Hospital Bratislava
Coordinator of this site? Confirm its status
BratislavaSlovakiaActive, not recruiting
3 F s.r.o.
Coordinator of this site? Confirm its status
KosiceSlovakiaActive, not recruiting
Fakultna Nemocnica Nitra
Coordinator of this site? Confirm its status
NitraSlovakiaActive, not recruiting
Euromedix a.s.
Coordinator of this site? Confirm its status
PetrzalkaSlovakiaActive, not recruiting
Nemocnica Poprad, a.s.
Coordinator of this site? Confirm its status
PopradSlovakiaActive, not recruiting
Nemocnica s poliklinikou Trebisov a.s.
Coordinator of this site? Confirm its status
TrebišovSlovakiaActive, not recruiting
Panhandle Eye Group, LLP. - Southwest Retina Specialists
Coordinator of this site? Confirm its status
AmarilloUnited StatesUnknown status
Win Retina
Coordinator of this site? Confirm its status
ArcadiaUnited StatesUnknown status
Texas Retina Associates
Coordinator of this site? Confirm its status
ArlingtonUnited StatesUnknown status
Austin Clinical Research, LLC
Coordinator of this site? Confirm its status
AustinUnited StatesUnknown status
Austin Research Center for Retina
Coordinator of this site? Confirm its status
AustinUnited StatesUnknown status
Austin Retina Associates
Coordinator of this site? Confirm its status
AustinUnited StatesUnknown status
Pacific Northwest Retina
Coordinator of this site? Confirm its status
BellevueUnited StatesUnknown status
Wills Eye Physician Mid Atlantic Retina
Coordinator of this site? Confirm its status
BethlehemUnited StatesUnknown status
Doctor Retina, PC
Coordinator of this site? Confirm its status
Beverly HillsUnited StatesUnknown status
Envision Ocular, LLC
Coordinator of this site? Confirm its status
BloomfieldUnited StatesUnknown status
Gailey Eye Clinic
Coordinator of this site? Confirm its status
BloomingtonUnited StatesUnknown status
Star Vision Research
Coordinator of this site? Confirm its status
BurlesonUnited StatesUnknown status
AVRUC
Coordinator of this site? Confirm its status
CarmelUnited StatesUnknown status
NC Retina Associates - Cary Research
Coordinator of this site? Confirm its status
CaryUnited StatesUnknown status
Mid Atlantic Retina
Coordinator of this site? Confirm its status
Cherry HillUnited StatesUnknown status
Blue Ocean Clinical Research
Coordinator of this site? Confirm its status
ClearwaterUnited StatesUnknown status
Retina Consultants of Southern Colorado
Coordinator of this site? Confirm its status
Colorado SpringsUnited StatesUnknown status
Connecticut Eye Consultants, P.C.
Coordinator of this site? Confirm its status
DanburyUnited StatesUnknown status
Rand Eye Institute
Coordinator of this site? Confirm its status
Deerfield BeachUnited StatesUnknown status
RSC Research, PLLC
Coordinator of this site? Confirm its status
DenverUnited StatesUnknown status
NJ Retina
Coordinator of this site? Confirm its status
EdisonUnited StatesUnknown status
Retina Vitreous Center, PLLC
Coordinator of this site? Confirm its status
EdmondUnited StatesUnknown status
Retina Associates
Coordinator of this site? Confirm its status
ElmhurstUnited StatesUnknown status
The Retina Partners
Coordinator of this site? Confirm its status
EncinoUnited StatesUnknown status
Eye Center of Northern Colorado, PC
Coordinator of this site? Confirm its status
Fort CollinsUnited StatesUnknown status
Retina Group of Florida
Coordinator of this site? Confirm its status
Fort LauderdaleUnited StatesUnknown status
RCOC Clinical Research Institute Inc.
Coordinator of this site? Confirm its status
FullertonUnited StatesUnknown status
Associated Retina Consultans
Coordinator of this site? Confirm its status
GilbertUnited StatesUnknown status
Global Research Management, Inc
Coordinator of this site? Confirm its status
GlendaleUnited StatesUnknown status
Retina Associates of Michigan
Coordinator of this site? Confirm its status
Grand BlancUnited StatesUnknown status
SightSera Clinical Research LLC
Coordinator of this site? Confirm its status
GreenwichUnited StatesUnknown status
Mid Atlantic Retina Specialists
Coordinator of this site? Confirm its status
HagerstownUnited StatesUnknown status
Cumberland Valley Retina Consultants
Coordinator of this site? Confirm its status
HagerstownUnited StatesUnknown status
Graystone Eye - Hickory Office
Coordinator of this site? Confirm its status
HickoryUnited StatesUnknown status
Berkeley Eye Center
Coordinator of this site? Confirm its status
HoustonUnited StatesUnknown status
Atlantis Eyecare
Coordinator of this site? Confirm its status
Huntington BeachUnited StatesUnknown status
Retina Consultants of Texas
Coordinator of this site? Confirm its status
KatyUnited StatesUnknown status
Colorado Retina Associates
Coordinator of this site? Confirm its status
LakewoodUnited StatesUnknown status
The Eye Institute of West Florida
Coordinator of this site? Confirm its status
LargoUnited StatesUnknown status
Retina Associates of Kentucky
Coordinator of this site? Confirm its status
LexingtonUnited StatesUnknown status
Retina Vitreous Surgeons of CNY, PC
Coordinator of this site? Confirm its status
LiverpoolUnited StatesUnknown status
South Coast Retina Center
Coordinator of this site? Confirm its status
Long BeachUnited StatesUnknown status
The Eye Care Institute
Coordinator of this site? Confirm its status
LouisvilleUnited StatesUnknown status
Valley Retina Institute P.A.
Coordinator of this site? Confirm its status
McAllenUnited StatesUnknown status
Retina Associates New Orleans
Coordinator of this site? Confirm its status
MetairieUnited StatesUnknown status
Retinal Consultants Medical Group
Coordinator of this site? Confirm its status
ModestoUnited StatesUnknown status
Northern California Retina Vitreous Associates Medical Group INC.
Coordinator of this site? Confirm its status
Mountain ViewUnited StatesUnknown status
Tennessee Retina
Coordinator of this site? Confirm its status
NashvilleUnited StatesUnknown status
NYC Retina
Coordinator of this site? Confirm its status
New YorkUnited StatesUnknown status
Kaiser Permanente
Coordinator of this site? Confirm its status
OaklandUnited StatesUnknown status
Illinois Retina Associates, S.C.
Coordinator of this site? Confirm its status
Oak ParkUnited StatesUnknown status
California Retina Consultants Oxnard Office
Coordinator of this site? Confirm its status
OxnardUnited StatesUnknown status
Retina Care Specialists
Coordinator of this site? Confirm its status
Palm Beach GardensUnited StatesUnknown status
Phoenix Retina Clinical Trials, LLC
Coordinator of this site? Confirm its status
PhoenixUnited StatesUnknown status
Associated Retina Consultants - Phoenix
Coordinator of this site? Confirm its status
PhoenixUnited StatesUnknown status
3RP/ Windy City Retina
Coordinator of this site? Confirm its status
PlainfieldUnited StatesUnknown status
Texas Retina Associates
Coordinator of this site? Confirm its status
PlanoUnited StatesUnknown status
Fort Lauderdale Eye Institute
Coordinator of this site? Confirm its status
PlantationUnited StatesUnknown status
Black Hills Regional Eye Institute
Coordinator of this site? Confirm its status
Rapid CityUnited StatesUnknown status
California Eye Specialists Medical Group, Inc.
Coordinator of this site? Confirm its status
RedlandsUnited StatesUnknown status
Retina Consultants of Southern California
Coordinator of this site? Confirm its status
RedlandsUnited StatesUnknown status
Retina Associates of Western NY, PC
Coordinator of this site? Confirm its status
RochesterUnited StatesUnknown status
VRMG Inc
Coordinator of this site? Confirm its status
SacramentoUnited StatesUnknown status
Retina Associates of South Texas
Coordinator of this site? Confirm its status
San AntonioUnited StatesUnknown status
TX RCTX Retina Consultants of Texas
Coordinator of this site? Confirm its status
San AntonioUnited StatesUnknown status
Retina Macula Institute of Arizona
Coordinator of this site? Confirm its status
ScottsdaleUnited StatesUnknown status
MedEye Associates
Coordinator of this site? Confirm its status
South MiamiUnited StatesUnknown status
Cascade Medical Research lnstitute, LLC
Coordinator of this site? Confirm its status
SpringfieldUnited StatesUnknown status
Retina Vitreous Associates of Florida - Saint Petersburg
Coordinator of this site? Confirm its status
St. PetersburgUnited StatesUnknown status
East Florida Eye Institute
Coordinator of this site? Confirm its status
StuartUnited StatesUnknown status
Retina Specialists of Tampa
Coordinator of this site? Confirm its status
TampaUnited StatesUnknown status
Tyler Retina Consultants
Coordinator of this site? Confirm its status
TylerUnited StatesUnknown status
North Carolina Retina Associates
Coordinator of this site? Confirm its status
Wake ForestUnited StatesUnknown status
Bay Area Retina Associates
Coordinator of this site? Confirm its status
Walnut CreekUnited StatesUnknown status
Virginia Retina Center
Coordinator of this site? Confirm its status
WarrentonUnited StatesUnknown status
VRCNY/Long Island Vitreoretinal Consultants
Coordinator of this site? Confirm its status
WestburyUnited StatesUnknown status
Haik Humble Eye Center
Coordinator of this site? Confirm its status
West MonroeUnited StatesUnknown status
Vitreo-Retinal Associates, PC
Coordinator of this site? Confirm its status
WorcesterUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.