NCT06686537RecruitingPhase 2
Convergent Mechanisms Underlying Reprometabolic Syndrome in Women
Convergent Mechanisms Underlying Reprometabolic Syndrome in Women and Sheep
Source: ClinicalTrials.gov · Last updated 21 Jul 2026
Brief summary (registry, in English)
Dr. Nanette Santoro proposes to test the specific question that obesity results in abnormal estradiol response at the level of the pituitary and hypothalamus. This will be shown in diminished pituitary sensitivity to gonadorelin releasing hormone with a reduced estradiol induced luteinizing hormone surge in obese women.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 20 (estimated)
- First submitted
- 11 Nov 2024
- Start date
- 25 Feb 2025
- Primary completion date
- Oct 2027
- Lead sponsor
- University of Colorado, Denver
- Diseases
- Obesity
- NCT number
- NCT06686537
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 20
- From 25 Feb 2025 to the primary completion date, Oct 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Has diabetes
- History of venous thromboembolism or known thrombophilia
Other
- Is a smoker
Who the study is looking for
- Age 18-38
- Regular menstrual cycles every 25-35 days
- No use of reproductive hormones within the past 3 months
- No use of medications interacting with reproductive hormones
- Agreement to use reliable barrier contraception or to abstain from intercourse for the duration of the study
- Normal thyroid stimulating hormone, prolactin and lipid profiles
- No more than 4 hours of moderate to vigorous intensity exercise per week
- No history of chronic disease impacting reproductive hormones
- No contraindications to administration of estradiol
- No history of estrogen dependent cancer
- Negative pregnancy test
Age in the registry: 18 years to 38 years · Sex: Female · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Colorado School of Medicine Coordinator of this site? Confirm its status | Aurora | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.