NCT06689956Recruiting
Outcomes of Low-Risk Endometrial Cancer With Isolated Tumor Cells in the Sentinel Lymph Nodes: A Prospective, Multicenter, Single-Arm Observational Study
Outcomes of Low-Risk Endometrial Cancer With Isolated Tumor Cells in the Sentinel Lymph Nodes: a Prospective Multicenter Single-Arm Observational Study
Source: ClinicalTrials.gov · Last updated 19 Feb 2026
Brief summary (registry, in English)
This study evaluates whether isolated tumor cells in the first lymph nodes near the tumor can tell researchers something important about the future of patients with a certain type of endometrial (uterine) cancer.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 212 (estimated)
- First submitted
- 13 Nov 2024
- Start date
- 4 Dec 2024
- Primary completion date
- 31 Oct 2029
- Lead sponsor
- Mayo Clinic
- Diseases
- Endometrial cancer, Childhood cancers
- NCT number
- NCT06689956
What you commit to
- Study type: Observational
- Planned participants: 212
- From 4 Dec 2024 to the primary completion date, 31 Oct 2029
- 20 sites in 10 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Prior neoadjuvant chemotherapy.
- Planning to receive adjuvant treatment.
- Presence of synchronous cancer (excluding non-melanoma skin cancer).
- Extent of disease in SLN: micrometastasis (\> 0.2 to ≤ 2.0 mm) or macrometastasis (\> 2.0 mm).
- Presence of substantial/extensive LVSI (≥ 5 vessels involved) at final pathology.
- Prior invasive cancer diagnosis within 5 years of study entry (excluding non-melanoma skin cancer).
Who the study is looking for
- Low-risk endometrial cancer, defined as endometrioid, grade 1 or 2, International Federation of Gynecology and Obstetrics (FIGO) 2009 stage IA (FIGO 2023 stages IA1 and IA2), without substantial/extensive LVSI (≥ 5 vessels involved) at final pathology. Patients with focal LVSI (\< 5 vessels involved) will be included.
- Complete surgical staging, including pelvic sentinel lymph node (SLN) biopsy per National Comprehensive Cancer Network (NCCN) guidelines and ultrastaging.
- Extent of disease in SLN: ITC (defined as tumor cell aggregates ≤ 0.2 mm or \< 200 cells)
- No adjuvant treatment after surgery
- Research consent provided.
Sex: All · Does not accept healthy volunteers
Sites (20)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Medical University of Vienna Coordinator of this site? Confirm its status | Vienna | Austria | Recruiting |
| AC Camargo Cancer Center Coordinator of this site? Confirm its status | São Paulo | Brazil | Recruiting |
| Hôpital Maisonneuve-Rosemont Coordinator of this site? Confirm its status | Montreal | Canada | Recruiting |
| Sunnybrook Health Sciences, University of Toronto Coordinator of this site? Confirm its status | Toronto | Canada | Recruiting |
| Ospedale Regionale di Lugano - Civico Coordinator of this site? Confirm its status | Lugano | Switzerland | Recruiting |
| University Hospital Essen Coordinator of this site? Confirm its status | Essen | Germany | Not yet recruiting |
| Hospital Materno Infantil Las Palmas Coordinator of this site? Confirm its status | Las Palmas | Spain | Recruiting |
| Hospital Universitario La Paz Coordinator of this site? Confirm its status | Madrid | Spain | Recruiting |
| Institut Universitaire du Cancer Toulouse - Oncopole Coordinator of this site? Confirm its status | Toulouse | France | Not yet recruiting |
| Meir Medical Center, Faculty of Medicine - Tel-Aviv University Coordinator of this site? Confirm its status | Kefar Sava | Israel | Not yet recruiting |
| European Institute of Oncology Coordinator of this site? Confirm its status | Milan | Italy | Recruiting |
| Fondazione IRCCS Istituto Nazionale Tumori Coordinator of this site? Confirm its status | Milan | Italy | Recruiting |
| IRCCS Fondazione San Gerardo dei Tintori Coordinator of this site? Confirm its status | Monza | Italy | Not yet recruiting |
| Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" Coordinator of this site? Confirm its status | Naples | Italy | Not yet recruiting |
| Policlinico Universitario Fondazione Agostino Gemelli Coordinator of this site? Confirm its status | Roma | Italy | Recruiting |
| University of Udine Coordinator of this site? Confirm its status | Udine | Italy | Not yet recruiting |
| Ospedale Michele e Pietro Ferrero Coordinator of this site? Confirm its status | Verduno | Italy | Not yet recruiting |
| Houston Methodist Hospital Coordinator of this site? Confirm its status | Houston | United States | Recruiting |
| Memorial Sloan-Kettering Cancer Center Coordinator of this site? Confirm its status | New York | United States | Recruiting |
| Mayo Clinic in Rochester Coordinator of this site? Confirm its status | Rochester | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.