NCT06694272Recruiting
Functional and Anatomical Visual Investigations in Patients With Early Forms of Age-related Macular Degeneration
Source: ClinicalTrials.gov · Last updated 21 Aug 2026
Brief summary (registry, in English)
Age-related macular degeneration (AMD) is the leading cause of visual impairment in industrialized countries. Anatomical examination findings at the early and intermediate stages of AMD are not sufficient to determine any functional alterations at these stages (e.g., alterations in microperimetry, multifocal electroretinogram (mfERG) and contrast sensitivity). Identifying early functional markers of the disease is a necessary first step in the development and clinical validation of treatments to slow progression to advanced disease.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 120 (estimated)
- First submitted
- 15 Nov 2024
- Start date
- 9 Apr 2025
- Primary completion date
- Apr 2031
- Lead sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
- Diseases
- Macular degeneration
- NCT number
- NCT06694272
What you commit to
- Study type: Observational
- Planned participants: 120
- From 9 Apr 2025 to the primary completion date, Apr 2031
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Neurological/neurodegenerative pathology that may prevent adequate performance of functional tests: advanced Parkinsonian syndromes, Benson's disease, Alzheimer's disease with visuomotor apraxia
- Other ophthalmological pathology that may affect anatomical and functional measurements: hypertonia / glaucoma or other optic neuropathy, media disorder causing reduced visual acuity, refraction \< -6.00D or \> +6.00D
- Other medical conditions preventing examinations or imaging (tremors, etc.)
Other
- Presence of geographic atrophy, even incipient, in one or both eyes
- Presence of patent or latent neovascularization visible on OCT b-scan or OCT-A in one or both eyes
- Compatibility of retinal signs with a "probable" differential diagnosis (bestrophinopathies, familial drusen, fundus flavimaculatus, fundus albipunctatus, hypovitaminosis A) in one or both eyes.
- Oculomotor pathology that may prevent proper performance of functional tests: nystagmus, oculomotor paralysis, in one or both eyes
Who the study is looking for
- Patient over 18 years of age
- Corrected visual acuity 10/10 in each eye
- Presence of retinal alteration(s) compatible with early (presence of macular drusen \< 125 μm) or intermediate (macular drusen \> 125 μm or pigmentary abnormalities) AMD in at least one of the two eyes :
- Conventional "soft" or "hard" drusen
- Cuticular drusen
- Reticulated pseudo-drusen
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hôpital Fondation A. de Rothschild Coordinator of this site? Confirm its status | Paris | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.