NCT06695429Recruiting
Supplementation With Beetroot Juice to Prevent Contrast Associated Nephropathy During Hospitalization for Acute Coronary Syndrome Without ST Elevation
Suplementación Con Zumo de REmolacha Para Prevenir la Nefropatía Asociada a Contraste Durante la hospitalización Por Síndrome Coronario Agudo Sin elevación Del ST
Source: ClinicalTrials.gov · Last updated 18 May 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The goal of this study is to compare the possible beneficial effect of beetroot juice supplementation versus the usual management during hospitalization to prevent contrast-induced nephropathy after cardiac catheterizations. The study includes patients diagnosed with non-ST elevation acute coronary syndrome with a possible indication for catheterism and high risk of kidney injury related to iodinated contrast. The intervention group will drink 500 mL (2 glasses daily, at breakfast and dinner) of beetroot juice added to the usual diet for 7 days or until hospital discharge and will receive the recommendation to maintain a diet rich in inorganic nitrates. The control group will receive the usual diet and recommendations. In both cases, other therapies will be prescribed to prevent contrast-induced nephropathy (hydration and statins) if there is no contraindication. Our hypothesis is that a compound present in beetroot juice, inorganic nitrates, can prevent the deterioration of kidney function related to contrast due to its vasodilatory effect, in addition to improving the subsequent prognosis of coronary heart disease due to its anti-inflammatory and antiproliferative effects, protector of the endothelium and inhibitor of platelet aggregation. Beetroot juice could also be beneficial in this context due to the antioxidant effect of the betalains it contains.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 130 (estimated)
- First submitted
- 14 Oct 2024
- Start date
- 7 Oct 2024
- Primary completion date
- 30 Sept 2026
- Lead sponsor
- Hospital General Universitario Santa Lucia
- Diseases
- Coronary artery disease
- NCT number
- NCT06695429
What you commit to
- Study type: Interventional
- Planned participants: 130
- From 7 Oct 2024 to the primary completion date, 30 Sept 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients receiving intravenous nitroglycerin for \> 1 hour before inclusion
Other illness
- Known hypersensitivity to beetroot or any of its allergens.
- Serious illnesses (not related to ACS or kidney failure), which limits their life expectancy to a period predictably less than 1 year.
Age
- \<18 years old or without capacity to give consent.
Other
- Refusal to participate in the study.
- Pregnant.
- Inability to take food orally
- On dialysis or predialysis at the time of inclusion.
- ACS with persistent ST segment elevation before inclusion.
- Shock or inotrope dependence at the time of inclusion
- PCI already performed before inclusion.
Who the study is looking for
- Diagnosis of Acute Coronary Syndrome without persistent ST segment elevation, with recommendation for invasive management according to the actual Clinical practice guidelines
- At least moderate or high risk of nephropathy associated with iodinated contrast (Mehran score (without including contrast volume) ≥ 6).
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital Universitario Santa Lucía Coordinator of this site? Confirm its status | Cartagena | Spain | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.