NCT06698120Not yet recruiting
Awake Prone Positioning for Severe Acute Chest Syndrome
Assessment of Efficacy and Safety of Awake Prone Positioning in Sickle Cell Anemia Patient Admitted in Intensive Care Unit for Severe Acute Chest Syndrome
Source: ClinicalTrials.gov · Last updated 2 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Acute chest syndrome (ACS) is the leading cause of admission to intensive care and the leading cause of death in patients with sickle cell disease. Irrespective of the cause of ACS, there is an heterogeneity in pulmonary ventilation/perfusion ratios, leading to worsening of the disease. Efficiency of awake prone positioning (APP) in acute respiratory failure (ARF) was particularly highlighted during the COVID-19 pandemic. Several physiological factors contribute to this benefit including an improvement in ventilatory drive and gas exchange. The investigator hypothesize that APP could lead to clinical improvement in ACS in terms of oxygenation and ventilatory drive, by improving the heterogeneity of ventilation
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 15 (estimated)
- First submitted
- 24 Apr 2024
- Start date
- Jan 2026
- Primary completion date
- Aug 2026
- Lead sponsor
- Assistance Publique - Hôpitaux de Paris
- Diseases
- Sickle cell disease
- NCT number
- NCT06698120
What you commit to
- Study type: Interventional
- Planned participants: 15
- From Jan 2026 to the primary completion date, Aug 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Pregnant or breastfeeding women
- Immediate need for intubation
- Impaired vigilance status (Glasgow scale score \< 12)
- Pneumothorax
- Haemodynamically unstable
- Thoracic trauma admission
- Severely obese with body-mass index higher than 40 kg/m²
- EIT contraindication: pacemaker, automatic implantable defibrillators, skin lesions facing the EIT belt, unstable rachis fracture or medullary lesions
Who the study is looking for
- Age \>18 years
- Major sickle cell anemia (SS, SC, Sβ)
- Admission in intensive care unit for ACS
- Registered in the French social insurance regime.
- Written, informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Service de Médecine Intensive Réanimation TENON Coordinator of this site? Confirm its status | Paris | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.