NCT06711432Recruiting
Different Intraoperative Blood Pressure Management on Postoperative Cognitive Function in Tumor Patients（PRECISION）
Effects of Different Intraoperative Blood Pressure Management Strategies on Postoperative Cognitive Function and Adverse Outcomes in Tumor Patients With High Risk Factors for Stroke
Source: ClinicalTrials.gov · Last updated 2 Dec 2024 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This is a randomized controlled study to explore whether perioperative blood pressure management with different strategies can reduce the incidence of delirium and postoperative cognitive impairment and serious perfusion related complications (persistent hypotension, new heart arrhythmia, cardiac insufficiency, new stroke, sudden death, etc.) within 30 days after stroke in cancer patients at high risk for stroke. Patients were randomly divided into: 1) strict blood pressure management group: norepinephrine or phenylephrine maintenance intraoperative MAP≥85 mmHg, and 2) conventional blood pressure management group: intraoperative routine blood pressure management (MAP≥65mmHg). The study included 424 subjects and was randomized to provide 90% efficacy. Secondary markers were unscrupulous cerebrovascular events (persistent hypotension, arrhythmia, cardiac insufficiency, new stroke, sudden death) within 30 days after surgery.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 214 (estimated)
- First submitted
- 10 Aug 2024
- Start date
- 18 Sept 2024
- Primary completion date
- 1 May 2026
- Lead sponsor
- Zhejiang Cancer Hospital
- Diseases
- Stroke
- NCT number
- NCT06711432
What you commit to
- Study type: Interventional
- Planned participants: 214
- From 18 Sept 2024 to the primary completion date, 1 May 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Emergency surgery
- Situations where strict blood pressure management is not appropriate, such as controlled hypotension during surgery.
Other illness
- Patients with severe heart disease (severe valvular disease, sick sinus syndrome, high atrioventricular block without pacemaker implantation), grade III or above Liver function impairment (Child-Pugh class C)
- Need kidney replacement therapy; New stroke \<3 months
- Preoperative history of mental illness, epilepsy, Parkinson's disease, or myasthenia gravis
- Speech, vision, or hearing impairment that prevents completion of a cognitive function assessment
Other
- Patients do not want to participate in the study
Who the study is looking for
- Patients with high-risk stroke (combined with 3 risk factors or more according to the stroke risk screening table)
- Patients who plan to undergo surgery for abdominal tumors (gynecological, urinary, hepatobiliary, and gastrointestinal tumors) under general anesthesia are expected to have surgery duration \>2 hours
- The ASA is rated as Class II or III
- Patients who underwent invasive arterial blood pressure monitoring before surgery signed informed consent
Age in the registry: 40 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Zhejiang Cancer Hospital Coordinator of this site? Confirm its status | Hangzhou | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.