NCT06713512Recruiting
InvEstigating oeStrogen Signalling and the Effect upoN the exTracelluar Matrix In pAtients With Obstructive Lung Disease
Source: ClinicalTrials.gov · Last updated 3 Dec 2024 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This study aims to understand the role of oestrogen in patients with asthma and Chronic Obstructive Pulmonary Disorder (COPD). Therefore, what is the effect of oestrogen in these participants compared to controls (those without disease). The study hypothesises that oestrogen loss in patients with asthma and COPD causes accelerated lung function decline and changes to lung structure. It will investigate if this is mediated by inflammation, immune host response or elastin and collagen changes. It is an observational prospective cohort study aiming to recruit healthy controls, and people with asthma or COPD), and/or the menopause.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 100 (estimated)
- First submitted
- 13 Sept 2024
- Start date
- 1 Dec 2024
- Primary completion date
- 1 Jan 2026
- Lead sponsor
- Guy's and St Thomas' NHS Foundation Trust
- Diseases
- Asthma
- NCT number
- NCT06713512
What you commit to
- Study type: Observational
- Planned participants: 100
- From 1 Dec 2024 to the primary completion date, 1 Jan 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Alcohol or recreational drug abuse, is defined as when the use is harmful as per NHS definition.
Other illness
- Known or suspected current pulmonary tuberculosis, HIV (human immunodeficiency virus), Hepatitis B Virus, Hepatitis C Virus.
- History of psychiatric, medical, or surgical disorders.
- History of advanced medical conditions with an expected prognosis of \< 3 years.
- Patients with a history of active cancer.
Other
- Pregnant
- Unable to provide written informed consent
- Patients on long term oxygen (ambulatory oxygen).
Who the study is looking for
- Men and women aged \> 18 years.
- For female participants: pre-menopausal, peri-menopausal and post-menopausal women can all be included.
- Participants willing and able to give informed consent for participation in the study.
- Healthy controls \<10 pack year history (participants without Asthma or COPD).
Age in the registry: 18 years to 99 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Guys St Thomas NHS Foundation Trust Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.