NCT06713668Active, not recruiting
Augmented Pacing for Shock in the Cardiac Intensive Care Unit
Augmented Pacing for Shock in the Cardiac Intensive Care Unit - A Pilot Patient-level Crossover Trial
Source: ClinicalTrials.gov · Last updated 6 May 2026
Brief summary (registry, in English)
The goal of this clinical trial is to learn if backup pacing at an increased rate improves hemodynamics in adults with relative bradycardia, a permanent pacemaker, and cardiogenic shock. The main question it aims to answer is: Does increasing the backup pacing rate to 100 beats per minute lead to improved cardiac index compared to a backup pacing rate of 75 beats per minute Participants who are already hospitalized in the Cardiovascular Intensive Care Unit with a permanent pacemaker and pulmonary artery catheter in place will be enrolled in this study. Participants will be exposed to each pacemaker rate in a randomized order with hemodynamics assessed after 10 minutes at each rate.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 25 (estimated)
- First submitted
- 1 Nov 2024
- Start date
- 22 Apr 2025
- Primary completion date
- 22 Apr 2027
- Lead sponsor
- Vanderbilt University Medical Center
- NCT number
- NCT06713668
What you commit to
- Study type: Interventional
- Planned participants: 25
- From 22 Apr 2025 to the primary completion date, 22 Apr 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Single chamber Implantable Cardiac Defibrillator
Other
- Sinus rhythm with a leadless pacemaker
- Ventricular Tachycardia or Ventricular Fibrillation arrest in last 48 hours
- Hemodynamic instability within the last 4 hours, defined as an increase in the dose of norepinephrine \> 10 mcg/min, an increase of epinephrine \> 10 mcg/kg/min, or initiation of a second vasopressor
- Alternative indication for pacing rate change (i.e Torsade de Pointes, Recurrent Ventricular Tachycardia)
- Comfort-focused care or anticipated death within 24 hours
- Mechanical circulatory support in place
- Newly discovered pacing system malfunction (lead displacement, loss of capture, elevated capture threshold, significant lead impedance change, battery depletion, undersensing or oversensing)
- Non-English Speaking
Who the study is looking for
- Adults (age 18 and older)
- Located in the CVICU
- FDA approved permanent pacemaker in place (inclusive of dual-chamber and Bi-Ventricular ICDs) with labeling that allows backup pacing setting at 100 bpm.
- Receiving a vasopressor or Inotrope for at least 4 hours
- Average HR ≤ 75 bpm over the last hour (on Telemetry review)
- Pulmonary artery catheter in place with functioning thermistor and pulmonary artery port.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Vanderbilt University Medical Center Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.