NCT06715579Recruiting
Cardiac Angiosarcoma International Registry
Source: ClinicalTrials.gov · Last updated 18 Feb 2026
Brief summary (registry, in English)
Primary cardiac angiosarcomas (PCA) are highly aggressive malignant heart tumors arising from the endothelial cells (ECs) lining the blood vessels of the heart and account for approximately 25%-30% of all primary cardiac malignancies. It is considered to be the most fatal and aggressive primary cardiac malignancy. This international registry aims to establish a large multicenter database of patients with cardiac angiosarcoma. Our objectives are: 1. Collect clinical data, including demographics, medical history, treatments, and outcomes, to build a comprehensive database. 2. Analyze data to evaluate and identify genetic, environmental, or lifestyle risk factors for cardiac angiosarcoma. 3. Evaluate the effectiveness of various treatments (surgery, chemotherapy, immunotherapy, radiation) to inform best practices. 4. Develop evidence-based guidelines and recommendations for prevention, diagnosis, treatment, and management based on registry data.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 500 (estimated)
- First submitted
- 28 Nov 2024
- Start date
- 1 May 2025
- Primary completion date
- May 2035
- Lead sponsor
- Immune Oncology Research Institute
- Diseases
- Childhood cancers, Sarcoma
- NCT number
- NCT06715579
What you commit to
- Study type: Observational
- Planned participants: 500
- From 1 May 2025 to the primary completion date, May 2035
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Cases where cardiac involvement is secondary to another primary malignancy
Other
- Patients who decline to provide informed consent.
Who the study is looking for
- Histological Confirmation: A confirmed diagnosis of cardiac angiosarcoma through histopathological examination, including subtypes such as hemangiosarcoma and epithelioid hemangiosarcoma.
- Diagnosis Timing: Eligible patients must have been diagnosed between January 2015 and January 2035.
- Geographical Representation: Participants should be from diverse geographical locations to ensure a comprehensive understanding of the disease across different populations.
- Treatment Status: Patients who have received any treatment (surgery, chemotherapy, immunotherapy or radiation) for cardiac angiosarcoma may be included to evaluate treatment outcomes.
- Informed Consent: For prospective patients, informed consent must be obtained before they are included in the registry.
- Clinical Data Availability: Relevant clinical data, including demographics, tumor characteristics (size, location), treatment regimens, and outcomes, must be available for analysis.
- Follow-Up Willingness: Participants should be willing to undergo follow-up assessments as part of the registry's data collection efforts.
Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Yeolyan Hematology and Oncology Center Coordinator of this site? Confirm its status | Yerevan | Armenia | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.