NCT06719947RecruitingPhase 2/3
HD-tDCS in Amyotrophic Lateral Sclerosis: A Multicenter Randomized Controlled Trial
High-Definition Transcranial Direct Current Stimulation (HD-tDCS) in Amyotrophic Lateral Sclerosis: A Multicenter Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 20 Jul 2026
Brief summary (registry, in English)
Amyotrophic Lateral Sclerosis (ALS) is a nervous system disease that causes muscle weakness and rapidly progresses to the loss of mobility and functionality. Studies suggest that High-Definition Transcranial Direct Current Stimulation (HD-tDCS) is a technique for modulating motor cortical hyperexcitability. However, evidence on the use of HD-tDCS as a neuromodulator of the diaphragmatic motor cortex in people with ALS is inconclusive.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2/3
- Study type
- Interventional
- Enrollment
- 80 (estimated)
- First submitted
- 30 Nov 2024
- Start date
- 28 Nov 2025
- Primary completion date
- Dec 2027
- Lead sponsor
- Universidade Federal do Rio Grande do Norte
- Diseases
- ALS (motor neurone disease)
- NCT number
- NCT06719947
What you commit to
- Study type: Interventional · Phase 2/3
- Planned participants: 80
- From 28 Nov 2025 to the primary completion date, Dec 2027
- 4 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Subjects with metallic brain implants or other electronic implants;
- Subjects with a cochlear implant;
Other illness
- Subjects with cardiac, respiratory, or musculoskeletal comorbidities;
- Subjects with epileptic activity or a history of epilepsy, or a family history of epilepsy;
- Subjects with a history of stroke or tumor;
- Subjects prone to severe hemodynamic fluctuations, acute infectious processes, and/or inflammatory conditions;
Other
- Subjects who are unable to understand or perform any of the study procedures;
- Subjects who do not agree to participate or voluntarily request withdrawal from the study at any time;
- Subjects using invasive mechanical ventilation;
- Subjects with a tracheostomy;
- Subjects with a pacemaker;
- Pregnant women at the time of recruitment;
- Subjects who are unable to complete the intervention protocol.
Who the study is looking for
- Both sexes; diagnosis of ALS according to the revised El Escorial criteria;
- Age between 18 and 80 years;
- Forced Vital Capacity greater than 50% of predicted;
- Sniff nasal inspiratory pressure greater than 40 cmH2O;
- A telephone number to contact the care team and who signed the study consent form.
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Universidade de Brasília - Campus Ceilândia Coordinator of this site? Confirm its status | Brasília | Brazil | Recruiting |
| PneumoCardioVascular Lab - HUOL/UFRN Coordinator of this site? Confirm its status | Natal | Brazil | Recruiting |
| Universidad do Chile Coordinator of this site? Confirm its status | Santiago | Chile | Not yet recruiting |
| Universidad Autónoma de Chile Coordinator of this site? Confirm its status | Santiago | Chile | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.