NCT06723249Completed
Stingless Bee Honey Augmentation in Major Depressive Disorders
The Effect of Stingless Bee Honey on BDNF, Oxidative Stress, Depressive Symptoms and Verbal Learning and Memory in Major Depressive Disorders: A Randomized Clinical Trial
Source: ClinicalTrials.gov · Last updated 23 Dec 2025
Brief summary (registry, in English)
The goal of this clinical trial is to learn if stingless bee honey can be an augmentation supplement in Major Depressive Disorder (MDD) in adults. It will also learn about the adverse effects of the honey. The main questions it aims to answer are: 1. Is there any effect of SBH on depressive symptoms between intervention and control groups in MDD? 2. Are there any effects of SBH on BDNF between intervention and control groups in MDD? 3. Are there any effects of SBH on oxidative stress between intervention and control groups in MDD? 4. Are there any effects of SBH on verbal learning and memory between intervention and control groups in MDD? There is no placebo. Participants will: Take stingless bee honey or nothing every day for 2 months Visit the clinic once every 4 weeks for checkups and tests Report adherence and adverse effects of stingless bee honey on a self-reported online questionnaires
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 45 (actual)
- First submitted
- 4 Dec 2024
- Start date
- 15 Dec 2024
- Primary completion date
- 10 Aug 2025
- Lead sponsor
- Hospital Universiti Sains Malaysia
- Diseases
- Depression
- NCT number
- NCT06723249
What you commit to
- Study type: Interventional
- Participants enrolled: 45
- From 15 Dec 2024 to the primary completion date, 10 Aug 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Currently taking honey not limited to stingless bee honey or taken honey not limited to stingless bee honey in the past one month.
Other illness
- Patients who with honey allergy or stingless bee honey allergy.
- comorbidity either with generalized anxiety disorder,
- panic disorder,
- social anxiety disorder,
- bipolar disorder,
- substance-use disorder,
- dementia,
- Alzheimer disease,
- hypertension,
- chronic kidney disease
Other
- Women in pregnancy or breast-feeding.
- suicidal ideation or attempt,
- diabetic,
Who the study is looking for
- Adults with ages 18 to 65
- with Major Depressive Disorder with scores of Beck Depression Inventory Malay version equal or more than 11
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital Universiti Sains Malaysia Coordinator of this site? Confirm its status | Kubang Kerian | Malaysia | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.