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NCT06725004CompletedPhase 3

Oxytocin Versus Human Chorionic Gonadotropin as Trigger in Ovulation Induction

Oxytocin Versus Human Chorionic Gonadotropin as Trigger in Ovulation Induction Cycles: A Randomized Controlled Trial

Source: ClinicalTrials.gov · Last updated 29 Aug 2025

Brief summary (registry, in English)

The goal of this clinical trial is to learn if injection oxytocin can be used as trigger in ovulation induction cycles in infertile women with polycystic ovary syndrome. The main questions it aims to answer are: * Does injection oxytocin have similar ovulation rate as injection human chorionic gonadotropin (hCG) when used as trigger? * Does injection oxytocin have similar pregnancy rate as injection human chorionic gonadotropin (hCG) when used as trigger? Researchers will compare injection oxytocin to injection hCG to see if injection oxytocin is as effective as injection hCG as trigger in ovulation induction cycles in infertile women with polycystic ovary syndrome. Participants will * Take injection oxytocin or injection hCG as trigger over three subsequent ovulation induction cycles * Be checked for ovulation by follicular rupture in TVS after 36 hours or raised serum progesterone level on day 7 after trigger * Be checked for pregnancy by urine pregnancy test kit after missed period

Status (registry)
Completed
Phase (registry)
Phase 3
Study type
Interventional
Enrollment
60 (actual)
First submitted
5 Dec 2024
Start date
1 Jan 2023
Primary completion date
31 Dec 2023
Lead sponsor
Shakeela Ishrat
NCT number
NCT06725004

What you commit to

  • Study type: Interventional · Phase 3
  • Participants enrolled: 60
  • From 1 Jan 2023 to the primary completion date, 31 Dec 2023
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Any drugs that affect the functions of hypothalamus, pituitary gland, and gonads

Other illness

  • Any pelvic pathology like pelvic inflammatory diseases
  • Any cardiovascular diseases or other systemic diseases
  • Any known hypersensitivity to oxytocin

Other

  • Male factor abnormality
  • Bilateral tubal block
  • Any uterine abnormality
  • Ovarian cysts
  • Hyperprolactinemia or thyroid dysfunction

Who the study is looking for

  • Infertile women with polycystic ovary syndrome
  • Age less than 40 years
  • Had ovulation induction with letrozole, with at least one mature follicle detected on folliculometry

Age in the registry: 20 years to 40 years · Sex: Female · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Bangabandhu Sheikh Mujib Medical University
Coordinator of this site? Confirm its status
DhakaBangladeshUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.