NCT06725342Completed
HNSCC Immuno-genomics Project
Immune Response Dynamics Predicted by Genomic Patterns in Head and Neck Cancer (HNSCC): a Translational Research Study of the Hellenic Cooperative Oncology Group
Source: ClinicalTrials.gov · Last updated 29 Jul 2026
Brief summary (registry, in English)
For locally advanced and recurrent / metastatic head \& neck squamous cell carcinoma (HNSCC), the is an unmet need for the development of efficient treatment combinations, particularly with immune checkpoint inhibitors. HNSCC have been characterized at the genetic / molecular level concerning characteristics of malignancy and potential clinical actionability ; currently, however, the integration of molecular characteristics of both the malignant cells and the host immune response are considered fundamental for the selection of treatment that best suits these patients . The primary objective of the NCR-17-12885 project is to classify HNSCC for the selection of optimal therapeutic interventions for the patients, based on genomic characteristics and mutational processes operating in these tumours and on the prevailing activated immune pathways.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 401 (actual)
- First submitted
- 4 Dec 2024
- Start date
- 19 Dec 2014
- Primary completion date
- 1 Jul 2019
- Lead sponsor
- Hellenic Cooperative Oncology Group
- Diseases
- Head and neck cancer
- NCT number
- NCT06725342
What you commit to
- Study type: Observational
- Participants enrolled: 401
- From 19 Dec 2014 to the primary completion date, 1 Jul 2019
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Age
- Age \<18 years old
Other
- Non-squamous cell carcinomas of the head and neck.
Who the study is looking for
- -Patients with locally advanced squamous cell carcinoma of the head and neck who were treated with concurrent chemoradiotherapy (CCRT) with or without induction chemotherapy (IC) or radical surgery +/- radiotherapy for laryngeal tumors.
Age in the registry: 18 years to 100 years · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.