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NCT06727214Active, not recruiting

Survival Benefits of Neoadjuvant Systemic Chemotherapy in Muscle Invasive Bladder Cancer

Survival Benefit of Neoadjuvant Systemic Chemotherapy in Muscle Invasive Bladder Cancer and Factors Affecting Its Response - Retrospective Study

Source: ClinicalTrials.gov · Last updated 3 Nov 2026

Brief summary (registry, in English)

Muscle-invasive bladder cancer (MIBC) is an aggressive disease with a high-risk of early metastasis and cancer specific mortality. The gold standard treatment of MIBC is radical cystectomy (RC) in conjunction with concomitant bilateral pelvic lymphadenectomy . While radical cystectomy remains a primary management strategy for MIBC, high rates of recurrence with surgery alone highlight the likelihood of occult micrometastatic disease at the time of diagnosis. Due to the development and implementation of neoadjuvant chemotherapy prior to radical cystectomy, the prognosis for MIBC patients undergoing radical cystectomy has improved .

Status (registry)
Active, not recruiting
Study type
Observational
Enrollment
87 (estimated)
First submitted
3 Dec 2024
Start date
4 Nov 2025
Primary completion date
4 Nov 2026
Lead sponsor
Sara Mahmoud Ahmed Mahmoud
NCT number
NCT06727214

What you commit to

  • Study type: Observational
  • Planned participants: 87
  • From 4 Nov 2025 to the primary completion date, 4 Nov 2026
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study design.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Patients treated with surgery firstly

Other illness

  • Non muscle invasive bladder cancer (NMIBC)

Other

  • Metastatic patients

Who the study is looking for

  • Age \>18
  • histological proven MIBC patient treated with neoadjuvant systemic chemotherapy( platinum based )

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Save your city in your profile to sort them by distance.

SiteCityCountrySite status
Assuit universty hospitals
Coordinator of this site? Confirm its status
AsyutEgyptUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.