NCT06729385Completed
Blood Proteome Profiling Identifies Biomarkers in Ischemic Stroke
The Blood Proteome Profiling Identifies Biomarkers Associated with Prognosis in Ischemic Stroke Due to Large Artery Atherosclerosis
Source: ClinicalTrials.gov · Last updated 21 Feb 2025
Brief summary (registry, in English)
Endovascular thrombectomy and intravenous thrombolysis have become key therapeutic approaches for acute ischemic stroke. However, due to time window limitations, many patients are unable to receive reperfusion therapy, and the majority only receive supportive treatment. Ischemic stroke-related complications, including edema and infection, gradually subside after 7 days post-stroke, with the patient's condition generally stabilizing. Endogenous repair mechanisms will play a critical role in the coming months. This study aims to predict prognostic biomarkers for ischemic stroke patients who have not undergone reperfusion therapy, using blood proteomics data. All samples in our study are derived from this experiment. Our goal is to elucidate the molecular mechanisms underlying post-reperfusion prognosis and to provide insights for optimizing stroke treatment strategies.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 80 (actual)
- First submitted
- 8 Dec 2024
- Start date
- 1 Dec 2024
- Primary completion date
- 20 Feb 2025
- Lead sponsor
- Capital Medical University
- Diseases
- Stroke
- NCT number
- NCT06729385
What you commit to
- Study type: Observational
- Participants enrolled: 80
- From 1 Dec 2024 to the primary completion date, 20 Feb 2025
- 4 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Severe infection or multiple organ failure.
- Untreated moderate or severe coronary artery stenosis, or a history of coronary artery bypass surgery.
- Malignant brain tumor or central nervous system (CNS) infection.
- Pre-existing neurological or psychiatric conditions that could confound the neurological or functional assessments.
Lab values
- Ongoing hemodialysis or peritoneal dialysis, or severe renal insufficiency characterized by a glomerular filtration rate (GFR) of less than 30 ml/min or serum creatinine levels exceeding 220 mmol/L (2.5 mg/dl).
- Baseline platelet count \<50 × 109/L.
Other
- Known intracranial aneurysm or cerebral arteriovenous malformation.
- Pregnancy or lactation at the time of admission.
Who the study is looking for
- Age ≥18.
- Clinical signs consistent with acute ischemic stroke (TOAST classification: large artery atherosclerosis)
- 7 to 30 days from symptom onset.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Xuanwu Hospital Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
| Liuyang Jili Hospital, Hunan, China Coordinator of this site? Confirm its status | Changsha | China | Unknown status |
| People's hospital of Xiushan Country Coordinator of this site? Confirm its status | Chongqing | China | Unknown status |
| Nanyang Nanshi Hospital Coordinator of this site? Confirm its status | Nanyang | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.