NCT06732817Completed
Personalized Dual-target RTMS for Patients with Refractory Schizophrenia
Personalized Repetitive Transcranial Magnetic Stimulation for Patients with Refractory Schizophrenia: an Open-label Study
Source: ClinicalTrials.gov · Last updated 13 Dec 2024
Brief summary (registry, in English)
The goal of this clinical trial is to evaluate the efficacy of personalized dual-target rTMS for treating patients with refractory schizophrenia and to investigate its underlying neural mechanisms using functional MRI. The main questions it seeks to address are: Does the dual-target rTMS protocol improve clinical symptoms in patients with refractory schizophrenia? What neural circuit changes, as assessed by functional MRI, occur following rTMS treatment? Participants will: Undergo personalized, dual-target rTMS treatment daily for 3 weeks. Complete baseline and post-treatment assessments, including clinical symptom scales (PANSS, HAMA, HAMD) and neuropsychological tests (MoCA, DST, VFT, Stroop Test, and AVLT). Have structural and resting-state functional MRI scans before and after treatment. Be monitored for any treatment-related adverse events.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 20 (actual)
- First submitted
- 10 Dec 2024
- Start date
- 1 Apr 2023
- Primary completion date
- 31 Oct 2024
- Lead sponsor
- Anhui Medical University
- Diseases
- Schizophrenia
- NCT number
- NCT06732817
What you commit to
- Study type: Interventional
- Participants enrolled: 20
- From 1 Apr 2023 to the primary completion date, 31 Oct 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- a history of rTMS or electroconvulsive therapy in the six months prior to the study; and
Other illness
- accompanied by other mental illnesses or histories;
- a history of severe head trauma or neurological disease;
Other
- pregnant;
- focal brain lesions on T1- or T2-weighted fluid-attenuated inversion-recovery MRI;
- metal objects in the head or any other contraindication to MRI.
Who the study is looking for
- diagnosed by independent psychiatrists using the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition;
- disease duration longer than six years;
- hospitalization two or more times;
- aged 18-60 years;
- a stable dosage of antipsychotic medication for at least four weeks before inclusion, and retention of this stable dose for the duration of the study.
Age in the registry: 18 years to 60 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Anhui Medical University Coordinator of this site? Confirm its status | Hefei | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.