NCT06733558WithdrawnEarly phase 1
Long-term Potentiation Disruption Underlying Cognitive Impairment in ECT
Source: ClinicalTrials.gov · Last updated 21 Jan 2026
Reason given: NIGMS, the funding agency, does not consider this study a clinical trial and they asked to remove from the system.
Brief summary (registry, in English)
Cognitive problems, like memory loss, are common after brain injuries like trauma or stroke. These problems make daily life harder, and the investigators don't yet know the best ways to help the brain recover. Scientists think that a process in the brain called long-term potentiation (LTP) is important for memory and learning. When LTP isn't working properly, it may cause problems with thinking and memory. But studying LTP in people is hard because it happens deep inside the brain. Our research uses a treatment called electroconvulsive therapy (ECT) to better understand LTP. ECT is a treatment for severe depression that works by causing a controlled seizure in the brain. While ECT often helps depression, it can temporarily cause memory and thinking problems, which usually improve over time. This makes ECT a good way to study how thinking and memory recover. The investigators will use a tool called electroencephalography (EEG) to measure brain activity during different stages of ECT treatment. EEG is a safe and non-invasive way to track changes in LTP. Specifically, the investigators will measure how the brain responds to visual signals using something called visual evoked potentials (VEPs). These signals can show how LTP is affected by ECT. The study's main goal is to track changes in LTP using VEPs during and after ECT. By studying these changes, the investigators hope to learn how ECT affects the brain and how it recovers. This could help improve treatments for brain injuries and other conditions that cause memory and thinking problems.
- Status (registry)
- Withdrawn
- Phase (registry)
- Early phase 1
- Study type
- Interventional
- Enrollment
- 0 (actual)
- First submitted
- 10 Dec 2024
- Start date
- 21 Jan 2025
- Primary completion date
- Jul 2026
- Lead sponsor
- University of New Mexico
- Diseases
- Depression, Bipolar disorder
- NCT number
- NCT06733558
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Defined neurological or neurodegenerative disorder (e.g., traumatic brain injury, epilepsy, Alzheimer's disease);
- other psychiatric conditions (e.g., schizophrenia, bipolar I disorder);
- current drug or alcohol use disorder (except for nicotine);
Other
- prisoners; and
- pregnancy (pre- menopausal participants will receive pregnancy test, which is clinically indicated for ECT and not part of study protocol).
Who the study is looking for
- diagnosis of major depressive disorder (MDD; with or without psychotic features) or bipolar 2 most recent episode depressed;
- clinical indications for ECT with right unilateral electrode placement including treatment resistance or a need for a rapid and definitive response,
- age range adults 18-85 years, and
- English-speaking (many of the neuropsychological tests are only available in English). Antidepressant medications will be continued as clinically indicated. To maintain feasibility and retention, as needed medications will be permitted for anxiety and insomnia.
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Domenici Hall | Albuquerque | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.