NCT06734546Recruiting
The Effect of Exercise on the Brain in Type 2 Diabetes
The Effect of Exercise of High vs. Moderate Intensity on the Brain in Type 2 Diabetes
Source: ClinicalTrials.gov · Last updated 31 Mar 2026
Brief summary (registry, in English)
The goal of this clinical trial is to learn if exercise training of high or moderate intensity is most optimal to improve brain health and prevent neurodegeneration in type 2 diabetes patients. The main question it aims to answer is: What is the effect of exercise training of high vs. moderate intensity on brain metabolism, brain perfusion, and cognition in type 2 diabetes? Researchers will compare the exercise training groups to a control group without exercise training to determine the effect of exercise training on the brain in type 2 diabetes. Participants will exercise for 6 months, 3 times per week. Before and after these 6 months, they will undergo: * a brain MRI scan * cognitive tests * blood sampling
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 75 (estimated)
- First submitted
- 25 Nov 2024
- Start date
- 8 Nov 2024
- Primary completion date
- Aug 2027
- Lead sponsor
- Hasselt University
- Diseases
- Type 2 diabetes
- NCT number
- NCT06734546
What you commit to
- Study type: Interventional
- Planned participants: 75
- From 8 Nov 2024 to the primary completion date, Aug 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- exogenous insulin therapy
Other illness
- psychological disorders
- history of coma, transient ischemic attack, head trauma, brain tumor, stroke, epilepsy, and other central nervous system diseases that could cause dementia or presence of dementia before T2DM
- suffering from any disease with significant impact on exercise intervention participation such as: chronic heart disease (e.g. valve insufficiency ≥ grade 2) or significant arrhythmias, cardiac events less than one year ago (myocardial infarction, coronary artery bypass graft, percutaneous coronary intervention), clinical heart failure (oedema, shortness of breath), percutaneous coronary intervention less than one year ago, chronic obstructive pulmonary disease (COPD), cerebrovascular or peripheral vascular disease
- severe hypertension (\>160/110 mmHg)
- ongoing cancer, severe neuropathy (limiting exercise participation)
- renal disease (GRF \<45 ml/min/1,73 m2)
Other
- MRI contraindications
- inability to regularly participate in the exercise intervention
- pregnancy
- breastfeeding
Who the study is looking for
- type 2 diabetes
- no insulin therapy
- 30-75 years old
- physically inactive
Age in the registry: 30 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hasselt University Coordinator of this site? Confirm its status | Hasselt | Belgium | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.