NCT06735014Recruiting
Multicenter ALS Imaging Study
Multicenter Longitudinal Imaging in ALS for Disease Biomarker Development
Source: ClinicalTrials.gov · Last updated 31 Jul 2026
Brief summary (registry, in English)
This is a multi-site study of ALS participants and healthy controls who will undergo brain and cervical spine MRIs and NfL blood testing at up-to 4 time points over the course of a year. The primary goal is to identify objective biomarkers of disease progression that are biologically relevant, linearly progressive, and sensitive to change.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 90 (estimated)
- First submitted
- 22 Nov 2024
- Start date
- 15 Sept 2024
- Primary completion date
- 31 Aug 2027
- Lead sponsor
- University of Minnesota
- Diseases
- ALS (motor neurone disease)
- NCT number
- NCT06735014
What you commit to
- Study type: Observational
- Planned participants: 90
- From 15 Sept 2024 to the primary completion date, 31 Aug 2027
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Individuals will be excluded if they have any condition that makes MRI unsafe or if they are unable to comply with instructions.
Other
- All participants will undergo a neurologic examination at enrollment. Control participants with clinically significant abnormal findings on neurological examination will be excluded from the study.
Criteria the registry did not label
- For participants with ALS:
- \< 36 months since onset of symptoms
- Definite, probable, lab-supported probable, or possible ALS by El Escorial criteria OR definite, probable, or possible ALS per Awaji-Shima criteria OR meets Gold Coast criteria
- Forced vital capacity within the last 90 days ≥ 60% of the predicted value
- Able to consent for themselves
- Able to read and speak English
- Clear of any contraindications for MRI
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Northwestern University Coordinator of this site? Confirm its status | Evanston | United States | Recruiting |
| University of Florida Coordinator of this site? Confirm its status | Gainesville | United States | Recruiting |
| University of Minnesota Coordinator of this site? Confirm its status | Minneapolis | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.