NCT06735924Active, not recruiting
Influence of Metabolic Syndrome on Endogenous Oxalate Synthesis
Non Alcoholic Fatty Liver Disease and Endogenous Oxalate Synthesis
Source: ClinicalTrials.gov · Last updated 29 May 2026
Brief summary (registry, in English)
This study aims to determine the daily rate of endogenous synthesis of oxalate using fasted urine collection and a low-oxalate controlled diet in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 28 (estimated)
- First submitted
- 11 Dec 2024
- Start date
- 26 Apr 2023
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- University of Alabama at Birmingham
- Diseases
- Fatty liver disease (MASLD/MASH)
- NCT number
- NCT06735924
What you commit to
- Study type: Interventional
- Planned participants: 28
- From 26 Apr 2023 to the primary completion date, 31 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Type 1 Diabetes Mellitus or treatment with insulin
- Use of weight loss medication, SGLT2 inhibitors, GLP-1 receptor agonists, osteoporosis medication, chronic NSAID
- Use of immunosuppressive medications
Other illness
- Evidence of other chronic liver disease, viral hepatitis
- history of alcoholism within 2 years of enrollment
- Chronic kidney disease with estimated Glomerular Filtration rate \< 60 ml/min/1.73m2
- Uncontrolled diabetes
- Uncontrolled hypertension
- History of gastric or intestinal surgery or resection that could potentially alter oxalate absorption
- Active malignancy or treatment for malignanacy within the last 12 months
Age
- Age \< 18 years
Other
- Inaccurate 24-hour urine collections
- Liver fat content \<5%
- Liver cirrhosis
- Contra-indication to Magnetic Resonance Imaging
- Pregnancy, lactation or intention to be
- Chronic fat malabsorption
- Known immuno-compromised status
Who the study is looking for
- age \>18 years
- History of MASLD, with liver fat content \> 5%
- Normal kidney function
- Stable medication for at least 1 month for diabetes mellitus if any
- Willingess to ingest fixed diets and stop dietary supplements for the study and come to UAB for visits
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Alabama at Birmingham Coordinator of this site? Confirm its status | Birmingham | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.