NCT06738394Recruiting
Enhancing Physical Function in Older Adults With Chronic Kidney Disease
Enhancing Physical Function in Older Adults With Chronic Kidney Disease (EPIC): A Pilot Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 26 Aug 2026
Brief summary (registry, in English)
The goal of this pilot randomized controlled trial is to examine the feasibility and safety of a 12-week high-velocity resistance training (HVRT) intervention in older adults with chronic kidney disease (CKD) stages 4-5 and to generate preliminary data to inform a future study investigating the efficacy of HVRT for improving muscle power and physical function. Researchers will compare HVRT to an attention control condition consisting of weekly group sessions covering topics on healthy lifestyle. This study seeks to: 1. Determine whether implementing an HVRT intervention is feasible and safe for mobility-limited older adults with advanced CKD. 2. Collect preliminary data on the efficacy of HVRT for improving muscle power and physical function in mobility-limited older adults with advanced CKD.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- First submitted
- 12 Dec 2024
- Start date
- 31 Jul 2025
- Primary completion date
- Jul 2027
- Lead sponsor
- Wake Forest University Health Sciences
- Diseases
- Chronic kidney disease
- NCT number
- NCT06738394
What you commit to
- Study type: Interventional
- Planned participants: 30
- From 31 Jul 2025 to the primary completion date, Jul 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Receiving renal replacement therapy (e.g. hemodialysis, peritoneal dialysis) or anticipated to start renal replacement therapy in the next 6 months
- Joint replacement or orthopedic surgery in the previous 6 months or planning to have surgery in the next 6 months months
- Currently receiving physical therapy or cardiopulmonary rehabilitation
Other illness
- Absolute contraindications to exercise testing according to ACSM:
- Acute myocardial infarction within the past 6 months Ongoing unstable angina Uncontrolled cardiac arrhythmia with hemodynamic compromise Active endocarditis Symptomatic severe aortic stenosis Decompensated heart failure Acute pulmonary embolism, pulmonary infarction, or deep venous thrombosis Acute myocarditis or pericarditis Acute aortic dissection
- Parkinson's disease
- Respiratory disease requiring oxygen
- Cancer requiring treatment
- Type I or insulin dependent Type II Diabetes
Other
- Dependent on a wheelchair
- Current participation in a resistance training program
- Scoring below 32 points on the Telephone Interview for Cognitive Status (TICS)
- Site PI/Study Clinician discretion regarding medical status, appropriateness of participation or concern about intervention adherence
Who the study is looking for
- Chronic kidney disease stages 3-5
- Capacity to complete physical exercise
- Lives within 20 miles of Wake Forest Reynolda Campus
- Fluent English speaker
- Does not plan to travel outside of home area for an extended period of time during study
- Willing to be randomized to either intervention group
Age in the registry: 65 years to 100 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Wake Forest University Health Sciences Coordinator of this site? Confirm its status | Winston-Salem | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.