NCT06740331Recruiting
Social Cognition, Memory, and Executive Functions in Bipolar Disorder and Major Depressive Disorder
Source: ClinicalTrials.gov · Last updated 13 Mar 2026
Brief summary (registry, in English)
Bipolar disorder (BD) are common psychiatric disorders often misdiagnosed, leading to delayed treatment. Even during stable phases, individuals with bipolar disorder experience residual cognitive impairments that affect their social functioning and quality of life. This study aims to explore social cognition deficits (e.g., emotional processing, theory of mind, attribution bias) and their relationship with executive functions (e.g., flexibility, inhibition, working memory) and memory in bipolar disorder and major depressive disorder, ultimately seeking to improve understanding of their functional outcomes. Social cognition and executive functions in BD are both state- and trait-related. One recent meta-analysis demonstrated impairment in social cognitive domains for manic, depressive, and euthymic bipolar disorders' patients but it remains unclear whether these social cognitive deficits in BD are due to executive functions and/or other confounding effects. Few studies have investigated the interdependency between these cognitive impairments in these two affective disorders while a better understanding of the link between executive functions and social cognition seems crucial in order to better characterize the nature of patients' deficits and thus their caring.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 180 (estimated)
- First submitted
- 13 Dec 2024
- Start date
- 7 Jan 2025
- Primary completion date
- 7 Jan 2028
- Lead sponsor
- CHU de Reims
- Diseases
- Depression, Bipolar disorder
- NCT number
- NCT06740331
What you commit to
- Study type: Interventional
- Planned participants: 180
- From 7 Jan 2025 to the primary completion date, 7 Jan 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- The presence of any alcohol use disorder or any other substance use disorder in the last six months, except for tobacco dependence
- A significant general medical illness, including neurological disorders or head trauma
- A sensorial impairment uncorrected (visual and/or hearing)
- Group 3: First-degree relatives of bipolar patients
- A diagnosis of schizophrenia or of bipolar disorder or of depressive disorder according to DSM-5 criteria
- The presence of any alcohol use disorder or any other substance use disorder in the last six months, except for tobacco dependence
- A significant general medical illness, including neurological disorders or head trauma
- A sensorial impairment uncorrected (visual and/or hearing)
- Group 4, 5, 6: Healthy control participants
- A diagnosis of schizophrenia or of bipolar disorder or of major depressive disorder according to DSM-5 criteria
- The presence of any alcohol use disorder or any other substance use disorder in the last six months, except for tobacco dependence
- Participants having one first-degree relative presenting an bipolar disorder or depressive disorder or schizophrenia according to DSM-5 criteria
- A significant general medical illness, including neurological disorders or head trauma
- A sensorial impairment uncorrected (visual and/or hearing)
Who the study is looking for
- Patients between 18 and 65 years old, men or women
- Having a diagnosis of bipolar disorder or depressive disorder
- No substantial change in treatment for 2 weeks preceding study enrollment
- Being a native French speaker
- Patients enrolled in the national healthcare insurance program
- Consenting to participate to the study
- Participants between 18 and 65 years old, men or women
- Participants having at least one first-degree relative presenting an bipolar disorder (parents, children, siblings)
- Being a native French speaker
- Patients enrolled in the national healthcare insurance program
- Consenting to participate to the study
- Participants between 18 and 65 years old, men or women
- Being a native French speaker
- Patients enrolled in the national healthcare insurance program
- Consenting to participate to the study
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CHU Reims Coordinator of this site? Confirm its status | Reims | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.