NCT06740552Completed
Evolocumab in Patients With Multivessel Coronary Disease After Acute Myocardial Infarction: A Target Trial Emulation
Effect of Evolocumab on Non-culprit Coronary Lesions in Patients With Multivessel Disease Following Acute Myocardial Infarction: A Target Trial Emulation
Source: ClinicalTrials.gov · Last updated 2 Feb 2026
Brief summary (registry, in English)
The goal of this Target Trial Emulation (TTE) study is to evaluate the effect of evolocumab on clinical prognosis in patients with multivessel disease (MVD) following acute myocardial infarction (AMI) who have deferred non-culprit vessel. The main question it aims to answer is: Does evolocumab lower risks of major adverse cardiovascular events (MACE) in patients with deferred non-culprit vessel after AMI?
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 1862 (actual)
- First submitted
- 15 Dec 2024
- Start date
- Jan 2021
- Primary completion date
- Dec 2024
- Lead sponsor
- Shanghai Zhongshan Hospital
- Diseases
- Coronary artery disease
- NCT number
- NCT06740552
What you commit to
- Study type: Observational
- Participants enrolled: 1862
- From Jan 2021 to the primary completion date, Dec 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Any cardiac surgery within 6 weeks prior to screening;
Other illness
- Cardiac shock, hemodynamically unstable, or severe heart failure (Killip IV)
- Contraindication or allergy to iodinated contrast agent;
- Malignancy except non-melanoma skin cancers, cervical, or breast ductal carcinoma in situ within the last 5 years;
Lab values
- Moderate to severe renal dysfunction, defined as an estimated glomerular filtration rate (eGFR) less than 30 mL/min/1.73m\^2 at screening;
Other
- Female subject is pregnant or breastfeeding or planning to become pregnant or breastfeed in short term.
Who the study is looking for
- Age ≥18 years old;
- Acute myocardial infarction diagnosed at hospital admission;
- Multivessel coronary artery disease diagnosed at primary invasive coronary angiography;
- Culprit vessel successfully revascularized;
- At lease 1 non-culprit vessel with ≥50% stenosis and deferred at the opinion of the operator, and no staged revascularization within 6 months.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Zhongshan Hospital,Fudan University Coordinator of this site? Confirm its status | Shanghai | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.