NCT06740708Active, not recruiting

Scaling Up Community-based Noncommunicable Disease Research Into Practice in Pokhara Metropolitan City of Nepal

Source: ClinicalTrials.gov · Last updated 15 Jun 2026

Brief summary (registry, in English)

The goal of this clinical trial is to evaluate whether a multifaceted community-based intervention, comprising 1) screening and lifestyle counseling by female community health volunteers (FCHVs); community health workers in Nepal, through home visits, and 2) regular Short Message Service (SMS) messages, can effectively reduce systolic blood pressure (SBP), lower fasting blood glucose, and increase smoking cessation rates among adults living in Pokhara with hypertension, type 2 diabetes, and smoking habits, respectively. The main research questions are: * Can FCHV home visits combined with regular mobile phone messages focused on blood pressure management reduce systolic blood pressure in adults with hypertension? * Can FCHV home visits combined with regular mobile phone messages focused on diabetes management lower fasting blood glucose levels in adults with type 2 diabetes? * Can FCHV home visits combined with regular mobile phone messages focused on smoking cessation increase the cessation rate among current smokers? Researchers will compare the intervention group with a usual care group, which does not receive regular FCHV home visits for managing the three aforementioned risk factors or mobile phone messages.

Status (registry): Active, not recruiting
Study type: Interventional
Enrollment: 2100 (actual)
First submitted: 13 Dec 2024
Start date: 28 Apr 2025
Primary completion date: 30 Nov 2026
Lead sponsor: Johns Hopkins Bloomberg School of Public Health
Diseases: High blood pressure, Type 2 diabetes
NCT number: NCT06740708

What you commit to

Study type: Interventional
Participants enrolled: 2100
From 28 Apr 2025 to the primary completion date, 30 Nov 2026
1 site in 1 country
Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study design.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

Diagnosed with secondary hypertension by health professionals
Diagnosed with other diabetes besides type 2 by health professionals

Lab values

Blood glucose \>250 mg/dL or \<54 mg/dL

Other

Blood pressure ≥180/120 mmHg or
Presenting with acute symptoms that may require hospitalizations, which includes but not limited to:
- Nausea, vomiting, diarrhea
- Abdominal pain
- Polyuria, polydipsia, polyphagia
- Loss of motor or sensory function
- Altered mental status.
- Chest pain, chest tightness
- Dyspnea, shortness of breath
- Fever
Diagnosed as terminally ill by a health professional, defined as life expectancy of 6 months or less.
Pregnant or intend to be pregnant

Who the study is looking for

Meeting at least one of the following three conditions
- Hypertensive, defined as
- BP≥140/90 mmHg at two separate measurements
- Type 2 diabetes, defined as
- Fingerprick glucose≥100 mg/dL, and plasma fasting glucose ≥126 mg/dL, and HbA1c≥6.5
- Current smoker, defined as
- Ever smoked ≥100 cigarettes in lifetime, and
- Currently smokes every day.
Registered on the voter list in Pokhara.
Not planning to migrate outside of Pokhara during the study period

Age in the registry: 40 years to 75 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Save your city in your profile to sort them by distance.

Site	City	Country	Site status
Pokhara Metropolitan City Coordinator of this site? Confirm its status	Pokhara	Nepal	Unknown status

Related publications

This page is information, not medical advice. Discuss any trial with your doctor.