NCT06740942Recruiting
Imaging and Serological Biomarkers of Autonomic Dysfunction After Ischemic Stroke
Source: ClinicalTrials.gov · Last updated 7 May 2026
Brief summary (registry, in English)
The goal of this observational study is to * to investigate the prevalence and time course of autonomic dysfunction in acute ischemic stroke patients; * to evaluate the influence of lesion location on autonomic dysfunction; * to identify patterns of structural and functional brain connectivity within the central autonomic control circuits associated with autonomic dysfunction; and * to explore causal models of the link between brain lesions; cardiac, immunological and endocrine biomarkers; and dysautonomia. Researchers will compare patients with acute ischemic stroke to patients with transient ischemic attacks to study the effect of acute ischemic brain lesions. Participants will * undergo cardiovascular autonomic function testing; * receive structural and functional MR imaging; * provide blood samples for determinaton of serological biomarkers auf dysautonomia.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 100 (estimated)
- First submitted
- 14 Dec 2024
- Start date
- 4 Aug 2025
- Primary completion date
- Sept 2026
- Lead sponsor
- Universitätsklinikum Hamburg-Eppendorf
- Diseases
- Stroke
- NCT number
- NCT06740942
What you commit to
- Study type: Observational
- Planned participants: 100
- From 4 Aug 2025 to the primary completion date, Sept 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- contraindications to MR imaging (e.g., claustrophobia, pregnancy, pacemakers, implants),
- previous structural brain damage (except leukoariosis due to cerebral small vessel disease),
- concomitant systemic illness that can lead to dysautonomia, such as an active infection, thyroid disease, or neurodegenerative disorder (e.g. PD, MSA).
Other illness
- In-hospital stroke,
- known moderate to severe dementia,
Lab values
- left heart failure with estimated left ventricular ejection fraction \< 50%,
Other
- hemodynamically relevant stenosis of the common or internal carotid artery, or
Who the study is looking for
- Diagnosis of either
- acute ischemic stroke with either an ischemic lesion visible on CT/MRI or persistent focal deficits 24 hours after symptom onset, or
- Transient ischemic attack with transient clinical deficits including motor or speech disturbance and not restricted to isolated vertigo/dizziness, visual disturbance, or sensory disturbance.
- symptom onset within 72h prior to hospital admission,
- a pre-stroke/TIA ability to walk without help from another person (modified Rankin scale score \< 4),
- age \> 18 years, and
- informed consent by either the patient or a legal representative (including a spouse)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Medical Center Hamburg-Eppendorf Coordinator of this site? Confirm its status | Hamburg | Germany | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.