NCT06742567RecruitingPhase 3
Apixaban Prophylaxis for Prevention of Left Ventricular Thrombus Following Anterior Myocardial Infarction
Apixaban Prophylaxis for Prevention of Left Ventricular Thrombus Following Anterior Myocardial Infarction: An Open Label, Randomized Clinical Trial (POTAMI)
Source: ClinicalTrials.gov · Last updated 19 Dec 2024 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The objective of this randomized controlled trial is to compare the safety and efficacy of low dose Apixaban (2.5 mg bid) in addition to guideline directed medical therapy vs guideline directed medical therapy alone in the prevention of left ventricular thrombus formation (after 30-days) following primary PCI in patients with acute anterior myocardial infarction with severe LV dysfunction.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 472 (estimated)
- First submitted
- 11 Dec 2024
- Start date
- 2 Dec 2024
- Primary completion date
- 30 Nov 2025
- Lead sponsor
- National Institute of Cardiovascular Diseases, Pakistan
- Diseases
- Coronary artery disease
- NCT number
- NCT06742567
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 472
- From 2 Dec 2024 to the primary completion date, 30 Nov 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients with previous anterior myocardial infarction or LAD revascularization procedures
Other illness
- History of recent CVA ( within past three months)
- Pregnant patients and those with hematological disorders
Lab values
- Recent ICH or major bleed requiring transfusion, low platelet counts \<100,000
Other
- Patients with cardiogenic shock
- Patients with LV thrombus
- Patients with advanced CKD (Cr \> 2 and those on hemodialysis)
- Patients with atrial fibrillation or other indications for chronic anticoagulation
Who the study is looking for
- Patients aged 18-65 years
- Presenting with acute anterior STEMI
- Severe LV dysfunction (EF\<35%) with antero-apical akinesis, dyskinesis, or aneurysm
- WIHTOUT evidence of LV thrombus.
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| NICVD Pakistan Coordinator of this site? Confirm its status | Karachi | Pakistan | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.