NCT06745648Recruiting
Carotid Sinus Massage in Trendelenburg Position for Headache Relief
Effectiveness of Carotid Sinus Massage in Modified Trendelenburg Position for Acute Headache Episodes: A Pilot Study
Source: ClinicalTrials.gov · Last updated 15 Jun 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Headaches significantly impact patients' quality of life, with tension-type headaches and migraines being among the most prevalent types. There is growing evidence suggesting that blood pressure regulation and baroreceptor activity play a role in headache pathophysiology. Carotid sinus massage (CSM), particularly when combined with the modified Trendelenburg position, may modulate autonomic nervous system activity to relieve headache symptoms. An initial open-label pilot study (n = 17) was completed, and the results were published in a preprint server for health sciences, the Medical Research Archive (medRxiv), demonstrating the feasibility, safety, and promising preliminary efficacy of CSM+T. Based on these findings, a follow-up randomized, sham-controlled, parallel-arm trial will further evaluate the efficacy of the treatment.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 18 (estimated)
- First submitted
- 13 Dec 2024
- Start date
- 21 Dec 2024
- Primary completion date
- 30 Dec 2025
- Lead sponsor
- Hospital Municipal Pedro T. Orellana
- Diseases
- Migraine
- NCT number
- NCT06745648
What you commit to
- Study type: Interventional
- Planned participants: 18
- From 21 Dec 2024 to the primary completion date, 30 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Any contraindication to carotid sinus massage, including:
- Carotid bruits
- Recent myocardial infarction
- History of stroke
- Known or suspected carotid artery stenosis
- Any contraindication to the Trendelenburg position, including:
- Increased intracranial pressure
- Respiratory distress
- Congestive heart failure
- History of syncope
- History of cardiac arrhythmias
Who the study is looking for
- Participants must be at least 16 years of age.
- Must have a diagnosis of one of the following, according to the International Classification of Headache Disorders (ICHD-3):
- Migraine
- Tension-type headache
- Mixed headache
- The headache episode must have started within the past 24 hours.
Age in the registry: 16 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital Pedro T.Orellana, Trenque Lauquen Coordinator of this site? Confirm its status | Trenque Lauquen | Argentina | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.