NCT06746142Active, not recruiting
Dosimetric Comparison of Target Volume, Heart and Left Lung in Post Mastectomy Radiotherapy (RT) of Left Sided Breast Cancer by Free Breathing (FB) Versus Deep Inspiration Breath Hold (DIBH) Technique
Free Breathing Versus Deep Inspiration Breath Hold Technique in Adjuvant Radiotherapy for Left Sided Breast Cancer: A Dosimetric Comparison of Target Volumes, Heart and Left Lung
Source: ClinicalTrials.gov · Last updated 24 Dec 2024
Brief summary (registry, in English)
Breast cancer is a leading cancer among Bangladeshi female. For breast cancer, there are different available treatment options according to the stage of disease. One of the important ones is radiotherapy (RT). Various side effects can occur during and after RT. Among the late side effects, numerous cardiac and pulmonary problems are significant specially in case of left sided breast cancer. In such cases, patients are being cured from cancer but the treatment itself endangering patients' general health and wellbeing by increasing risk of future life threatening cardiac and pulmonary diseases. Studies from around the world have shown that, during RT of left sided breast cancer, holding the breath for certain time after deep inspiration can reduce the radiation doses to heart and left lung without compromising doses to the chest wall. As a result, they can avoid the extra risk of treatment related late toxicities. This study will look at the utility and efficacy of Deep Inspiration Breath Hold (DIBH) RT over free breathing (FB) RT in reducing the heart and left lung doses without compromising the dose to the target volumes in left sided post mastectomy breast cancer patient, which is the main objective of this study.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 50 (estimated)
- First submitted
- 17 Dec 2024
- Start date
- 17 Jul 2024
- Primary completion date
- Jul 2025
- Lead sponsor
- Nishat Tasnim
- Diseases
- Lung cancer
- NCT number
- NCT06746142
What you commit to
- Study type: Interventional
- Planned participants: 50
- From 17 Jul 2024 to the primary completion date, Jul 2025
- 4 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patient received any chemotherapy other than Doxorubicin, Cyclophosphamide and taxane (Paclitaxel/ Docetaxel) in any settings (neoadjuvant or adjuvant).
- Patients with previous history of radiotherapy to chest.
Other illness
- Left sided breast cancer patient underwent BCS.
- Patients who have comorbidities that would hinder DIBH (extreme obesity, mental disorder, hypoacusis etc.).
- Known case of patients with respiratory diseases.
- Known case of patients with ischemic heart diseases.
- Male breast cancer patients.
- Bilateral breast cancer patients.
Age
- Age ˂ 18 years.
Other
- Pregnant or lactating women.
Who the study is looking for
- Histopathologically proven left sided invasive breast cancer patients who underwent modified radical mastectomy.
- Post mastectomy patients for whom radiotherapy including supraclavicular irradiation is indicated.
- Patients having ECOG performance status up to 1.
Age in the registry: 18 years to - · Sex: Female · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Bangabandhu Sheikh Mujib Medical University Coordinator of this site? Confirm its status | Dhaka | Bangladesh | Unknown status |
| Delta Hospital Limited, Dhaka Coordinator of this site? Confirm its status | Dhaka | Bangladesh | Unknown status |
| Lab Aid Cancer Hospital, Dhaka Coordinator of this site? Confirm its status | Dhaka | Bangladesh | Unknown status |
| Combined Military Hospital, Dhaka Coordinator of this site? Confirm its status | Dhaka | Bangladesh | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.