NCT06752499Completed
rTMS Combined With Motor Training for the Treatment of Upper Limb Motor Dysfunction in Stroke Patients
Source: ClinicalTrials.gov · Last updated 30 Apr 2026
Brief summary (registry, in English)
The goal of this clinical trials is to investigate the effectiveness of online repetitive transcranial magnetic stimulation (rTMS) in enhancing upper limb motor rehabilitation during the subacute and chronic phase of stroke. It will also learn about the safety of online rTMS intervention methods. The main questions it aims to answer are: 1. Does rTMS combined with motor training improve motor rehabilitation in patients？ 2. Does repetitive transcranial magnetic stimulation (rTMS) combined with motor training enhance the upper limb motor rehabilitation ability in stroke patients by strengthening the functional coupling of the motor circuit to achieve functional reorganization of the brain network ? Researchers will compare online rTMS to offline and sham stimulation in stroke patients to see if online rTMS works to alleviate motor dysfunction in multicenter multicenter, blinded and controlled trial. Participants will: 1. randomized to one group(online, offline or sham); 2. receive rTMS treatment for 10 days, with 5 working days per week for a total of two weeks; 3. receive magnetic resonance imaging (MRI) and electroencephalogram (EEG) evaluations before and after the entire treatment; 4. conduct scales and MEP assessment one day before the treatment, as well as one day, one month, and three months after the treatment.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 60 (actual)
- First submitted
- 27 Dec 2024
- Start date
- 20 Feb 2023
- Primary completion date
- 10 Sept 2025
- Lead sponsor
- Ruijin Hospital
- Diseases
- Stroke
- NCT number
- NCT06752499
What you commit to
- Study type: Interventional
- Participants enrolled: 60
- From 20 Feb 2023 to the primary completion date, 10 Sept 2025
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Patients with severe heart, lung, liver, kidney diseases and malignant tumors;
- Those with a history of aphasia, severe cognitive impairment or mental illness;
- Patients who have had a history of epileptic seizures in the last month or are taking anti-epileptic drugs recently;
- People with metal implants, pacemakers, skull defects or other conditions that prevent them from undergoing TMS.
Other
- Those with severe visual or hearing impairments, unable to communicate normally;
Who the study is looking for
- The patient is first diagnosed with stroke through neurological examination, CT or MRI scan.
- The vital signs are stable and there is a certain degree of upper limb motor dysfunction.
- The age is between 20 and 80 years old.
- The cognitive ability is not significantly affected and the patient can cooperate with various examinations and assessments, with a MMSE score ≥ 20 points.
- There are no serious complications (such as pneumonia, heart failure, urinary tract infection or malnutrition).
- There is no pathological condition that is a contraindication for TMS in the medical history (for example, patients with metal in the brain, such as aneurysm clips, patients with a cardiac pacemaker, pregnant women, or those with a history of epileptic seizures).
- The patient or guardian agrees to sign the informed consent form.
Age in the registry: 20 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Shanghai Ruijin Hospital, affiliated to Shanghai Jiao Tong University, School of medicine, Coordinator of this site? Confirm its status | Shanghai | China | Unknown status |
| Shanghai Yang Zhi Rehabilitation Hospital Coordinator of this site? Confirm its status | Shanghai | China | Unknown status |
| Changhai Hospital Coordinator of this site? Confirm its status | Shanghai | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.