NCT06755372Recruiting
The Role of Toll-like Receptor-4 in Periodontitis Patients With End-stage Renal Disease in a Sample of Egyptian Population
Source: ClinicalTrials.gov · Last updated 4 Jul 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Chronic kidney disease (CKD) is a significant public health issue in Egypt, leading to end-stage renal disease (ESRD). ESRD patients often suffer from oral abnormalities due to the disease and medications. Periodontitis is linked to systemic diseases, including renal disease, with inflammation playing a key role. TLR4 genetic variations may influence susceptibility to CKD and periodontitis. This study investigates the association between TLR4 \[Gly/Thr (rs2149356)\] polymorphism and chronic periodontal disease in ESRD patients in Egypt.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 100 (estimated)
- First submitted
- 31 Dec 2024
- Start date
- 1 Apr 2025
- Primary completion date
- 1 Jul 2025
- Lead sponsor
- Ain Shams University
- Diseases
- Chronic kidney disease
- NCT number
- NCT06755372
What you commit to
- Study type: Observational
- Planned participants: 100
- From 1 Apr 2025 to the primary completion date, 1 Jul 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Individuals with any systemic disease or long-term medication use
- Individuals with systemic diseases other than diabetes
- History of malignancy
Other
- Smokers
- Group II: ESRD Patients with Periodontitis
- Individuals with kidney transplants
- Smokers
Who the study is looking for
- Age: 30 to 60 years
- Gender: Both male and female
- Diagnosed with Periodontitis stage II and/or stage III
- Systemically healthy, no history of systemic diseases
- Not on long-term medications
- Age: 30 to 60 years
- Gender: Both male and female
- Diagnosed with end-stage renal disease (ESRD) on regular hemodialysis
- Diagnosed with Periodontitis stage II and/or stage III
- Unrelated Egyptians from a similar socioeconomic status, residing in the same geographical area
- Underlying type 2 diabetes mellitus
Criteria the registry did not label
- Group I: Healthy Subjects with Periodontitis
Age in the registry: 30 years to 60 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| hemodialysis center at Benha University Hospital. Coordinator of this site? Confirm its status | Al Fayyum | Egypt | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.