NCT06756620Completed
Investigation of the Etiology of Hypertension and Endothelial Damage in Patients With Cytochrome P450 Oxidoreductase Deficiency
Source: ClinicalTrials.gov · Last updated 8 Sept 2025
Brief summary (registry, in English)
This study investigates the etiology of hypertension and endothelial damage in patients with Cytochrome P450 Oxidoreductase (POR) deficiency. The study involves comparing ambulatory blood pressure monitoring (ABPM), endothelial biomarkers (Prostaglandin E2, Thromboxane B2, and Nitric Oxide levels), and capillaroscopy findings between POR deficiency patients and healthy controls.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 51 (actual)
- First submitted
- 26 Dec 2024
- Start date
- 24 Dec 2024
- Primary completion date
- 12 Aug 2025
- Lead sponsor
- Ozge Bayrak Demirel
- Diseases
- High blood pressure
- NCT number
- NCT06756620
What you commit to
- Study type: Observational
- Participants enrolled: 51
- From 24 Dec 2024 to the primary completion date, 12 Aug 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of medications other than physiologic hydrocortisone
Other illness
- Presence of an acute illness or other pathology identified during the study. Nail-biting habit or manicure within the last 14 days (due to potential impact on capillaroscopy results)
- Kidney, endocrine, or vascular pathologies that may cause hypertension
- History of smoking or hand trauma
Who the study is looking for
- Genetically confirmed diagnosis of Cytochrome P450 Oxidoreductase (POR) deficiency
- Diagnosis of POR deficiency before the age of 18.
- Written informed consent provided by the participant and/or their legal guardian.
Age in the registry: 7 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Istanbul University Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.