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NCT06757010CompletedPhase 2

A Study of NE3107 in Early Parkinson's

A Double-Blind, Randomized, Placebo-controlled, Study of NE3107 in Subjects With Early Parkinson's Disease

Source: ClinicalTrials.gov · Last updated 11 Aug 2026

Brief summary (registry, in English)

The goal of this clinical trial is to learn if bezisterim can treat movement symptoms of Parkinson's disease in patients that are 45 to 80 years old, in generally good physical and mental health, and are nearing the need for treatment to relieve their symptoms but have not yet been prescribed any form of levodopa or drug with similar activity. The main questions it aims to answer are: * Will bezisterim decrease movement symptoms of Parkinson's disease? * What medical problems do participants have when taking bezisterim? Researchers will compare the effects of bezisterim treatment to placebo (a look-alike substance that contains no drug) to see if bezisterim works to treat movement symptoms of Parkinson's disease. Participants will * have a physical examination that includes an electrocardiogram * take drug or placebo twice daily for four months * visit a clinical site or receive an at home visit seven times over the course of five months

Status (registry)
Completed
Phase (registry)
Phase 2
Study type
Interventional
Enrollment
57 (actual)
First submitted
24 Dec 2024
Start date
26 Mar 2025
Primary completion date
1 May 2026
Lead sponsor
BioVie Inc.
NCT number
NCT06757010

What you commit to

  • Study type: Interventional · Phase 2
  • Participants enrolled: 57
  • From 26 Mar 2025 to the primary completion date, 1 May 2026
  • 4 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • has taken levodopa or another similar drug for the motor symptoms of PD

Other illness

  • major mental health or physical illness
  • medical history of major mental or physical illness

Other

  • a known or strongly suspected familial cause for PD diagnosis

Who the study is looking for

  • 45 years to 80 years of age
  • diagnosed with idiopathic Parkinson's Disease (PD) within 18 months
  • nearing the need for symptomatic therapy
  • agree to use birth control measures
  • provide voluntary consent
  • willing to allow blood collection for DNA methylation analysis
  • pass all screening tests and procedures

Age in the registry: 45 years to 80 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (4)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Dent Neurologic
Coordinator of this site? Confirm its status
AmherstUnited StatesUnknown status
NeuroScience Research Center LLC
Coordinator of this site? Confirm its status
CantonUnited StatesUnknown status
QUEST Research Institute
Coordinator of this site? Confirm its status
Farmington HillsUnited StatesUnknown status
Science 37 (Nationwide Site)
Coordinator of this site? Confirm its status
MorrisvilleUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.