A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HRS-4729 Injection in Healthy Subjects

Prior treatment

• A history of significant gastrointestinal disease or related symptoms, conditions affecting gastric emptying, or prior gastrointestinal surgery.
• Subjects who have had a major surgery or severe trauma within 6 months prior to screening, or who are planned for surgical procedures during the trial period.
• Participation in any drug or medical device clinical trial within 3 months prior to screening.

Other illness

• A history of current significant disease in the neurological, psychiatric, cardiovascular, gastrointestinal, respiratory, genitourinary, endocrine, hematologic, or immune systems, as determined by the investigator, which would render the subject unsuitable for participation in this trial.
• Known or suspected history of drug abuse or substance dependence, or positive urine drug screen during the screening period.

Lab values

• Any abnormal physical examination, vital signs, laboratory tests, chest X-ray and abdominal ultrasound findings deemed clinically significant by the investigator, rendering the subject unsuitable for participation.

Other

• Clinically significant abnormalities on 12-lead ECG as determined by the investigator.

• Voluntarily provides written informed consent prior to the initiation of any study-related activities and demonstrates understanding of the procedures and methods involved in the study, agreeing to adhere strictly to the clinical trial protocol to complete the study.
• Male or female subjects; aged 18 to 55 years.
• Self-reports no more than a 5 kg change in body weight during the 3 months prior to screening (including the screening visit).