NCT06768437Recruiting
The Role of Epicardial Adiposity in Heart Failure With Preserved Ejection Fraction
Source: ClinicalTrials.gov · Last updated 30 Apr 2026
Brief summary (registry, in English)
In this study the investigators are aiming to recruit 130 patients with heart failure with preserved ejection fraction who are obese and non-obese to undergo CT and MRI scans, as well as some other investigations including blood tests, to help investigate if having more fat around the heart leads to worse heart function in this condition. This may lead to the development of new treatments aimed at lowering fat levels around the heart and in the rest of the body, specifically to treat HFpEF.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 130 (estimated)
- First submitted
- 28 Nov 2024
- Start date
- 12 Feb 2025
- Primary completion date
- Aug 2027
- Lead sponsor
- University of Leicester
- Diseases
- Heart failure
- NCT number
- NCT06768437
What you commit to
- Study type: Observational
- Planned participants: 130
- From 12 Feb 2025 to the primary completion date, Aug 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Severe primary valvular heart disease
- HFpEF due to infiltrative cardiomyopathy (cardiac amyloidosis or sarcoidosis), genetic hypertrophic cardiomyopathy, restrictive cardiomyopathy/pericardial disease or congenital heart disease
- Known heritable, idiopathic or drug-induced pulmonary arterial hypertension
Lab values
- LV ejection fraction \<45%
- Recovered ejection fraction (previous ejection fraction \<40%) unless reduced ejection fraction was in context of tachycardia induced cardiomyopathy (eg atrial fibrillation/atrial flutter)
- Absolute contraindications to cardiac CT or MRI including estimated glomerular filtration rate (eGFR) ≤30ml/min/1.73m2. Patients with MRI-compatible devices are be excluded.
Other
- Women who are pregnant
Who the study is looking for
- Participant is willing and able to give informed consent for participation in the study.
- Aged ≥18 years old
- Diagnosed with HFpEF by an experienced cardiologist or signs and symptoms of heart failure with a HFA-PEFF score ≥5
- Able to understand written English
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Glenfield Hospital, University Hospitals of Leicester Coordinator of this site? Confirm its status | Leicester | United Kingdom | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.