NCT06768827Recruiting

New Mechanisms of Obesity

Pathogenic Mechanisms of Obesity and Its Cardiometabolic Complications

Source: ClinicalTrials.gov · Last updated 28 Jan 2026

Brief summary (registry, in English)

Given the pervasiveness of Pediatric Obesity, it is imperative to understand its pathophysiology and develop alternative strategies to reverse this condition. Herein, investigators propose to elucidate the interaction between colonic fermentation and insulin resistance in modulating metabolism in youth with obesity.

Status (registry): Recruiting
Study type: Interventional
Enrollment: 55 (estimated)
First submitted: 6 Jan 2025
Start date: 13 Nov 2025
Primary completion date: 31 Mar 2030
Lead sponsor: Yale University
Diseases: Obesity
NCT number: NCT06768827

What you commit to

Study type: Interventional
Planned participants: 55
From 13 Nov 2025 to the primary completion date, 31 Mar 2030
1 site in 1 country
Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

medications affecting insulin resistance such as metformin, GLP-1 analogues; -

Other illness

endocrinopathies (e.g., Cushing syndrome);

Other

Pregnancy;
substance abuse;
high fibers intake (\> 30g/day) as assessed by a 3-day food record.

Who the study is looking for

Age 15 to 22 years
In puberty (girls and boys: Tanner stage III-V);
BMI \>85th

Age in the registry: 15 years to 22 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

Site	City	Country	Site status
Yale University Coordinator of this site? Confirm its status	New Haven	United States	Recruiting

This page is information, not medical advice. Discuss any trial with your doctor.