NCT06772558Not yet recruiting
Desflurane Potentially Induces Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Perioperative Procedures by Modulating Cdc42 and Clock Proteins
The Potential Mechanism by Which Desflurane Induces Postoperative Cognitive Dysfunction in Elderly Perioperative Patients Involves the Modulation of Cdc42 and Clock Proteins, and Their Related Signaling Pathways.
Source: ClinicalTrials.gov · Last updated 14 Jan 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This clinical trial investigates whether desflurane induces postoperative cognitive dysfunction (POCD) in elderly patients undergoing perioperative procedures by modulating Cdc42 and Clock proteins. The primary research questions are: (1) Does desflurane administration contribute to POCD in this patient population? and (2) Are alterations in Cdc42 and Clock protein levels associated with desflurane-induced POCD in elderly patients? To address these questions, elderly patients will be administered desflurane for anesthesia maintenance. Postoperative assessments will then compare blood levels of Cdc42 and Clock proteins, and examine related signaling pathways, between a control group and a POCD group. Study participants will receive desflurane anesthesia maintained at a Bispectral Index (BIS) value of 40-60. Postoperative cognitive function will be assessed on the second day using the Montreal Cognitive Assessment (MoCA), and participants will be categorized into either a control group or a POCD group based on MoCA performance. Cognitive function and blood levels of Cdc42 and Clock proteins will be recorded. Furthermore, the study will also investigate associated signaling pathways.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 9 Jan 2025
- Start date
- 1 Feb 2025
- Primary completion date
- 1 May 2025
- Lead sponsor
- Xiaguang Duan
- Diseases
- Coronary artery disease
- NCT number
- NCT06772558
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 1 Feb 2025 to the primary completion date, 1 May 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Pre-existing diagnosis of dementia or any other neurodegenerative disease that could affect cognitive function
- History of severe psychiatric disorders, including psychosis, severe depression, or bipolar disorder
- Unstable angina, uncontrolled hypertension, or a history of myocardial infarction within the past 6 months
- Severe chronic obstructive pulmonary disease (COPD) with significant respiratory compromise, or other significant respiratory disease
- History of stroke, transient ischemic attack (TIA), or other significant neurological disorders
- History of alcohol or drug abuse
- Known allergy or contraindication to any of the study drugs
- Other conditions at the discretion of the investigator that could interfere with the conduct of the study or the interpretation of the results
Lab values
- Severe hepatic or renal impairment, defined as Child-Pugh class C for liver disease, or glomerular filtration rate (GFR) \< 30 mL/min/1.73 m2 for kidney disease
Other
- Preoperative Montreal Cognitive Assessment (MoCA) score \< 20
- Patients with visual, auditory, or language impairments that would interfere with cognitive testing.
Who the study is looking for
- Age \> 70 years
- American Society of Anesthesiologists (ASA) physical status classification I-III
- Scheduled to undergo elective surgery requiring general anesthesia with desflurane
- Able and willing to provide voluntary written informed consent
- Able to understand the study procedures and complete follow-up assessments
Age in the registry: 70 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Inner Mongolia Baogang Hospital Coordinator of this site? Confirm its status | Baotou | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.