NCT06776315Completed
The Effect of Exercise Training on lncRNA Expression in Asthma
Examining the Effect of Exercise Training on LncRNA MALAT1 Expression in Asthma Patients
Source: ClinicalTrials.gov · Last updated 4 Feb 2026
Brief summary (registry, in English)
The goal of this observational study is to examine the effects of traditional respiratory rehabilitation and respiratory muscle strengthening training added to this program at the genetic level in asthma. The main questions it aims to answer are: * Does respiratory muscle strengthening exercise added to respiratory rehabilitation in asthmatic patients have additional benefits on rehabilitation outcome measures such as exercise capacity, shortness of breath, and muscle strength? * Does the gain obtained with respiratory muscle strengthening in asthmatic patients increase the quality of life of patients and have a positive effect on their psychological state? * Does respiratory rehabilitation applied to asthmatic patients have an effect on genetic changes? * Does respiratory muscle strengthening training applied in addition to respiratory rehabilitation in asthmatic patients have an effect on genetic changes? * Participants will be included in two different respiratory rehabilitation programs with and without respiratory muscle training, and pre- and post-treatment rehabilitation criteria and genetic changes will be compared.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 84 (actual)
- First submitted
- 13 Dec 2024
- Start date
- 13 Jul 2023
- Primary completion date
- 1 Dec 2024
- Lead sponsor
- Saglik Bilimleri Universitesi
- Diseases
- Asthma
- NCT number
- NCT06776315
What you commit to
- Study type: Interventional
- Participants enrolled: 84
- From 13 Jul 2023 to the primary completion date, 1 Dec 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Having received oral corticosteroid treatment within the last 4 weeks,
Other illness
- Having had a recent (within the last month) respiratory tract infection,
- Having a smoking history of over 10 packs/years or having a smoking history within 6 months of quitting smoking,
- Eosinophilic Granulomatosis with Polyangiitis (EGPA) and Allergic Bronchopulmonary Aspergillosis (ABPA),
- History of malignancy,
- Presence of a musculoskeletal, neurological or cardiac disease that would prevent exercise.
Other
- Having a Body Mass Index \>30,
- Vasculitis,
- Pregnancy,
Who the study is looking for
- Being between the ages of 18 and 75,
- Being diagnosed with severe persistent asthma by a chest physician in accordance with the Global Initiative for Asthma (GINA) guideline criteria,
- Patients with type 2 inflammation markers. According to the accepted standard; Peripheral eosinophils ≥150/µL and/or induced sputum eosinophils ≥2% - Airway hyperresponsiveness (PC20 methacholine \< 8 mg/mL) and/or bronchodilator response (\>12% or 200 mL improvement in % predicted FEV1 following 400 mg salbutamol inhalation)
Age in the registry: 18 years to 75 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Health Sciences Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.