NCT06777355Completed
Association Between Portal Flow Pulsatility and Right Ventricular Dysfunction in the Postoperative Period of Cardiac Surgery
Liver Infusion Flow Evaluation With ultraSound for Assessment of Right Ventricular Function: a Single cEnter Cohort Study (LIFESAVE)
Source: ClinicalTrials.gov · Last updated 1 Dec 2025
Brief summary (registry, in English)
Right ventricular dysfunction (RVD) after cardiac surgery is associated with ischemia and myocardial injury. While echocardiographic measures like Tricuspid Annular Plane Systolic Excursion (TAPSE) are frequently used to assess ventricular function, they have limitations in terms of accuracy. The pulmonary artery catheter remains the gold standard for assessing RVD. This dysfunction is associated with an increased risk of both renal and hepatic failure, complications that significantly affect patient outcomes. Doppler ultrasound has emerged as a valuable tool in predicting these complications, particularly in monitoring portal circulation and hepatic perfusion. This study aims to explore the association between portal flow pulsatility and RVD after cardiac surgery.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 32 (actual)
- First submitted
- 3 Jan 2025
- Start date
- 24 Feb 2025
- Primary completion date
- 4 Jul 2025
- Lead sponsor
- CMC Ambroise Paré
- Diseases
- Heart failure
- NCT number
- NCT06777355
What you commit to
- Study type: Observational
- Participants enrolled: 32
- From 24 Feb 2025 to the primary completion date, 4 Jul 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patient at risk for pulmonary artery catheter insertion:
- Tricuspid valve surgery
- Pacemaker or implantable cardioverter-defibrillator in place
Other
- Patient presenting a confounding factor for altered portal flow:
- Tricuspid regurgitation greater than grade 2
- Known cirrhosis
- Patient with intrahepatic arteriovenous malformations
- Patient with an esophageal tract abnormalities contraindicating transesophageal echocardiography (TEE)
- Pregnant or breastfeeding women
- Patient unable to understand the information provided
- Patient under guardianship, curatorship, or legal protection
- Patients deprived of liberty
Who the study is looking for
- Patient aged at least 18 years
- Patients undergoing cardiac surgery with cardiopulmonary bypass and presenting at least one risk factor for postoperative complications, including:
- Patient over 60 years old
- Preoperative left ventricular ejection fraction (LVEF) \< 50%
- Surgery involving both coronary artery bypass grafting and valve procedures
- Mitral valve surgery
- Preoperative creatinine clearance less than 30 ml/min
- Patient having signed the informed consent form in accordance with regulations
- Patient covered by social security or an equivalent healthcare system
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CMC Ambroise Paré Hartmann Coordinator of this site? Confirm its status | Neuilly-sur-Seine | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.