NCT06778135Recruiting
Neocortical Microarchitecture of Executive Function
Neocortical Microarchitecture of Executive Function Using Large-scale Intracranial Electrophysiology
Source: ClinicalTrials.gov · Last updated 5 Nov 2026
Brief summary (registry, in English)
This study is being done to the determine the ability and utility of using the Neuropixels probes in the human brain. A Neuropixels probe will be inserted into and removed from the brain of awake human patients who are undergoing awake Deep Brain Stimulation (DBS) surgery.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 15 (estimated)
- First submitted
- 10 Jan 2025
- Start date
- 25 Jul 2025
- Primary completion date
- Oct 2027
- Lead sponsor
- University of Colorado, Denver
- Diseases
- Parkinson disease
- NCT number
- NCT06778135
What you commit to
- Study type: Interventional
- Planned participants: 15
- From 25 Jul 2025 to the primary completion date, Oct 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Inability to tolerate awake surgery as determined by the treating neurologist and study neurosurgeon.
Other illness
- Moderate, or severe cognitive impairment as determined by a licensed neuropsychologist during routine neuropsychological evaluation.
- Moderate or severe cognitive impairment or executive function deficits as determined by neuropsychological testing.
Other
- Inability to safely access the dorsal lateral prefrontal cortex for an entry location.
- Evidence of a clinically significant abnormality on preoperative imaging.
Who the study is looking for
- Diagnosis of Parkinson's disease and refractory to medications requiring deep brain stimulation
- Aged 45-85
- Able to provide informed consent
- Normal neuropsychiatric evaluation that includes tests of executive function demonstrating no greater than mild impairments, within expectation for Parkinson's disease.
- Medically able to undergo deep brain stimulation surgery as evaluated by study neurosurgeon.
- Surgical plan includes an entry point that can safely be placed in the dorsal lateral PFC.
- Able to tolerate awake deep brain stimulation surgery with a plan for the case to be done awake.
- Able to tolerate 25 additional minutes of awake surgery.
- Able to participate and comply with tasks adequately, including instructions provided in English.
Age in the registry: 45 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Colorado Coordinator of this site? Confirm its status | Aurora | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.